Efecto antifúngico de quitosán de alto peso molecular en cepas de Candida sp aisladas de muestras clínicas / Antifungal effect of high molecular weight chitosan on Candida spp isolated from clinical samples
Rev. chil. infectol
;
26(6): 515-519, dic. 2009. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-536831
ABSTRACT
Chitosan is a D-glucosamine polysaccharide derived from chitin that displays an antimicrobial activity against bacteria and fungi. Objective:
to evaluate the antifungal effect of high molecular weight chitosan (HMWC) in clinical strains of Candida spp.Methodology:
the susceptibility of forty strains of Candida spp. to HMWC was studied (16 C albicans, 11 C glabrata, 5 C. tropicalis, 5 C krusei, 2 C parapsilosis and 2 C.famatd) by broth microdilution at pH 7.0 and pH 4.0.Results:
of 40 strains, only 2 were inhibited at pH 7.0 and corresponded to ATCC control strains (C. krusei 6258 and C parapsilosis 22019). On the other hand, 37/40 strains (92.5 percent) were inhibited by concentrations lower than 1.25 mg/mL of HMWC at pH 4.0.Conclusion:
these results show that HMWC, presents activity against clinical Candida spp. strains, including C glabrata, and that this activity is present at acid pH (4.0). This compound could potentially be used in vulvovaginal candidiasis since it occurs at pH 4.0-4.5.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Candida
/
Chitosan
/
Antifungal Agents
Language:
Spanish
Journal:
Rev. chil. infectol
Journal subject:
Communicable Diseases
Year:
2009
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de Chile/CL
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