Neurosífilis en pacientes portadores y no portadores de VIH: descripción y comparación de dos cohortes históricas / Neurosyphilis in the patients with and without HIV infection: description and comparison of two historical cohorts
Rev. chil. infectol
;
26(6): 540-547, dic. 2009. tab, graf, ilus
Article
in Spanish
| LILACS
| ID: lil-536834
ABSTRACT
Neurosyphilis follows a more aggressive and different clinical course in HIV-infected patients compared to patients with normal immunity. Two historical series of patients with a diagnosis of neurosyphilis between 1995 and 2008 were compared they included a group of 15 patients with y and 28 patients without HIV infection. Probability of neurosyphilis in patients with positive serum VDRL was increased in patients infected with HIV comparedto HIV negative patients (OR 62.37 IC95 percent (32.1-119.1) p value< 0,001). Predominant clinical manifestations in neurosyphilis in the HIV negative group were ocular abnormality, vascular encephalic and spinal cord lesions. In the HIV positive group, they were fever, ocular abnormalities and headache. There were no differences in cerebrospinal fluid characteristics between both groups. Neurosyphilis was diagnosed even in patients with blood VDRL of < 132, that happened in 17.8 percent of the HIV positive patients with blood and in 60 percent of t he HIV negative patients. Penicillin sodium given at dose ¡Ý than 18.000.000 IU/day IV during 14 days was the most common treatment. In patients with clinical neurosyphilis, 93 percent of HIV negative group, and 54.2 percent of HIV positive group had persistent neurological after-effects. Three HIV positive patients died due to causes not related to neurosyphilis.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
AIDS-Related Opportunistic Infections
/
HIV Seronegativity
/
Neurosyphilis
Type of study:
Diagnostic study
/
Etiology study
/
Incidence study
/
Observational study
/
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. chil. infectol
Journal subject:
Communicable Diseases
Year:
2009
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Hospital Cl¨ªnico Universidad Cat¨®lica de Chile/CL
/
Hospital Dr. Sotero Del R¨ªo/CL
/
Hospital Dr. Sotero Del Río/CL
/
Hospital Padre Hurtado/CL
/
Hospital Regional de Temuco/CL
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