Relationship between insulin and hypogonadism in men with metabolic syndrome / Relação entre insulina e hipogonadismo em homens com síndrome metabólica
Arq. bras. endocrinol. metab
; 53(8): 1005-1011, nov. 2009. tab, graf
Article
in En
| LILACS
| ID: lil-537038
Responsible library:
BR1.1
ABSTRACT
OBJECTIVE:
To evaluate the incidence of hypogonadism in men with metabolic syndrome and its correlation with serum insulin levels.METHODS:
Observational, transversal study with 80 men with metabolic syndrome. The individuals were divided into two groups Group 1 56 patients (70 percent) with total testosterone > 300 ng/dL (normal gonadal function); Group 2 24 patients (30 percent) with total testosterone < 300 ng/dL (hypogonadic).RESULTS:
The subjects from Group 2 compared to Group 1 presented higher body mass index (BMI), waist and hip circumferences, insulin, homeostasis model assessment insulin resistance index (Homa-IR) and beta cell (Homa-β), and triglycerides, but lower SHBG and free testosterone values. Inverse correlations between insulin levels and total testosterone and SHBG, as well as between Homa-IR and total testosterone were observed.CONCLUSION:
In this series of men with metabolic syndrome, hypogonadism was associated with insulin resistance and may be a marker of metabolic abnormalities.RESUMO
OBJETIVO:
Avaliar a frequência de hipogonadismo em homens portadores da síndrome metabólica e a sua correlação com a concentração sérica de insulina.MÉTODOS:
Estudo observacional e transversal com 80 homens portadores da síndrome metabólica. Os sujeitos foram estratificados em dois grupos Grupo 1 56 pacientes (70 por cento) com testosterona total > 300 ng/dL (função gonadal normal); Grupo 2 24 pacientes (30 por cento) com testosterona < 300 ng/dL (hipogonádicos).RESULTADOS:
Os sujeitos do Grupo 2 comparados ao Grupo 1 tinham maior índice de massa corporal (IMC), de circunferências do quadril e da cintura, insulina, Homa-IR, Homa-β e triglicerídeos, mas tinham valores menores de SHBG e testosterona livre. Observou-se correlação inversa da concentração de insulina com a de testosterona total e SHBG, e do Homa-IR com a concentração de testosterona total.CONCLUSÃO:
Nos indivíduos estudados, a presença de hipogonadismo esteve associada à resistência à insulina, podendo ser um marcador de alterações metabólicas.Key words
Full text:
1
Index:
LILACS
Main subject:
Testosterone
/
Metabolic Syndrome
/
Hypogonadism
/
Insulin
Type of study:
Observational_studies
/
Prevalence_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Humans
/
Male
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
Arq. bras. endocrinol. metab
Journal subject:
ENDOCRINOLOGIA
/
METABOLISMO
Year:
2009
Type:
Article