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Inhibition of Trypanosoma cruzi proline racemase affects host-parasite interactions and the outcome of in vitro infection
Coutinho, Leticia; Ferreira, Marcelo Alves; Cosson, Alain; Batista, Marcos Meuser; Batista, Denise da Gama Jaén; Minoprio, Paola; Degrave, Wim M; Berneman, Armand; Soeiro, Maria de Nazaré Correia.
  • Coutinho, Leticia; Laboratório de Genômica Funcional e Bioinformática. BR
  • Ferreira, Marcelo Alves; Laboratório de Genômica Funcional e Bioinformática. BR
  • Cosson, Alain; Institut Pasteur. Laboratoire d'Immunobiologie des infections à Trypanosoma. Département d'Immunologie. Paris. FR
  • Batista, Marcos Meuser; Instituto Oswaldo Cruz-Fiocruz. Laboratório de Biologia Celular. Rio de Janeiro. BR
  • Batista, Denise da Gama Jaén; Instituto Oswaldo Cruz-Fiocruz. Laboratório de Biologia Celular. Rio de Janeiro. BR
  • Minoprio, Paola; Institut Pasteur. Laboratoire d'Immunobiologie des infections à Trypanosoma. Département d'Immunologie. Paris. FR
  • Degrave, Wim M; Laboratório de Genômica Funcional e Bioinformática. BR
  • Berneman, Armand; Institut Pasteur. Laboratoire d'Immunobiologie des infections à Trypanosoma. Département d'Immunologie. Paris. FR
  • Soeiro, Maria de Nazaré Correia; Instituto Oswaldo Cruz-Fiocruz. Laboratório de Biologia Celular. Rio de Janeiro. BR
Mem. Inst. Oswaldo Cruz ; 104(8): 1055-1062, Dec. 2009. ilus
Article in English | LILACS | ID: lil-538164
ABSTRACT
Proline racemase is an important enzyme of Trypanosoma cruzi and has been shown to be an effective mitogen for B cells, thus contributing to the parasite's immune evasion and persistence in the human host. Recombinant epimastigote parasites overexpressing TcPRAC genes coding for proline racemase present an augmented ability to differentiate into metacyclic infective forms and subsequently penetrate host-cells in vitro. Here we demonstrate that both anti T. cruzi proline racemase antibodies and the specific proline racemase inhibitor pyrrole-2-carboxylic acid significantly affect parasite infection of Vero cells in vitro. This inhibitor also hampers T. cruzi intracellular differentiation.
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Full text: Available Index: LILACS (Americas) Main subject: Trypanosoma cruzi / Proline / Enzyme Inhibitors / Amino Acid Isomerases / Host-Parasite Interactions Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2009 Type: Article Affiliation country: Brazil / France Institution/Affiliation country: Institut Pasteur/FR / Instituto Oswaldo Cruz-Fiocruz/BR / Laboratório de Genômica Funcional e Bioinformática/BR

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Full text: Available Index: LILACS (Americas) Main subject: Trypanosoma cruzi / Proline / Enzyme Inhibitors / Amino Acid Isomerases / Host-Parasite Interactions Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2009 Type: Article Affiliation country: Brazil / France Institution/Affiliation country: Institut Pasteur/FR / Instituto Oswaldo Cruz-Fiocruz/BR / Laboratório de Genômica Funcional e Bioinformática/BR