Absence of Fas-L aggravates renal injury in acute Trypanosoma cruzi infection
Mem. Inst. Oswaldo Cruz
;
104(8): 1063-1071, Dec. 2009. ilus, tab
Article
in English
| LILACS
| ID: lil-538165
ABSTRACT
Trypanosoma cruzi infection induces diverse alterations in immunocompetent cells and organs, myocarditis and congestive heart failure. However, the physiological network of disturbances imposed by the infection has not been addressed thoroughly. Regarding myocarditis induced by the infection, we observed in our previous work that Fas-L-/- mice (gld/gld) have very mild inflammatory infiltration when compared to BALB/c mice. However, all mice from both lineages die in the early acute phase. Therefore, in this work we studied the physiological connection relating arterial pressure, renal function/damage and cardiac insufficiency as causes of death. Our results show that a broader set of dysfunctions that could be classified as a cardio/anaemic/renal syndrome is more likely responsible for cardiac failure and death in both lineages. However, gld/gld mice had very early glomerular deposition of IgM and a more intense renal inflammatory response with reduced renal filtration, which is probably responsible for the premature death in the absence of significant myocarditis in gld/gld.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Chagas Disease
/
Fas Ligand Protein
/
Acute Kidney Injury
/
Myocarditis
Type of study:
Etiology study
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2009
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Centro de Criação de Animais de Laboratório/BR
/
Instituto Oswaldo Cruz-Fiocruz/BR
/
Universidade Federal Fluminense/BR
/
Universidade Federal de São Paulo/BR
/
Universidade Federal do Rio de Janeiro/BR
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