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Cardiovascular activity of the n-butanol fraction of the methanol extract of Loranthus ferrugineus Roxb
Ameer, O. Z; Salman, I. M; Siddiqui, M. J. A; Yam, M. F; Sriramaneni, R. N; Sadikun, A; Ismail, Z; Shah, A. M; Asmawi, M. Z.
  • Ameer, O. Z; Universiti Sains Malaysia. School of Pharmaceutical Sciences. Department of Physiology and Pharmacology. Minden. MY
  • Salman, I. M; Universiti Sains Malaysia. School of Pharmaceutical Sciences. Department of Physiology and Pharmacology. Minden. MY
  • Siddiqui, M. J. A; Universiti Sains Malaysia. School of Pharmaceutical Sciences. Department of Pharmaceutical Chemistry. Minden. MY
  • Yam, M. F; Universiti Sains Malaysia. School of Pharmaceutical Sciences. Department of Physiology and Pharmacology. Minden. MY
  • Sriramaneni, R. N; Universiti Sains Malaysia. School of Pharmaceutical Sciences. Department of Physiology and Pharmacology. Minden. MY
  • Sadikun, A; Universiti Sains Malaysia. School of Pharmaceutical Sciences. Department of Pharmaceutical Chemistry. Minden. MY
  • Ismail, Z; Universiti Sains Malaysia. School of Pharmaceutical Sciences. Department of Pharmaceutical Chemistry. Minden. MY
  • Shah, A. M; Universiti Sains Malaysia. School of Pharmaceutical Sciences. Department of Physiology and Pharmacology. Minden. MY
  • Asmawi, M. Z; Universiti Sains Malaysia. School of Pharmaceutical Sciences. Department of Physiology and Pharmacology. Minden. MY
Braz. j. med. biol. res ; 43(2): 186-194, Feb. 2010. graf, tab
Article in English | LILACS | ID: lil-538234
ABSTRACT
We investigated the vascular responses and the blood pressure reducing effects of different fractions obtained from the methanol extract of Loranthus ferrugineus Roxb. (F. Loranthaceae). By means of solvent-solvent extraction, L. ferrugineus methanol extract (LFME) was successively fractionated with chloroform, ethyl acetate and n-butanol. The ability of these LFME fractions to relax vascular smooth muscle against phenylephrine (PE)- and KCl-induced contractions in isolated rat aortic rings was determined. In another set of experiments, LFME fractions were tested for blood pressure lowering activity in anesthetized adult male Sprague-Dawley rats (250-300 g, 14-18 weeks). The n-butanol fraction of LFME (NBF-LFME) produced a significant concentration-dependent inhibition of PE- and KCl-induced aortic ring contractions compared to other fractions. Moreover, NBF-LFME had a significantly higher relaxant effect against PE- than against high K+-induced contractions. In anesthetized Sprague-Dawley rats, NBF-LFME significantly lowered blood pressure in a dose-dependent manner and with a relatively longer duration of action compared to the other fractions. HPLC, UV and IR spectra suggested the presence of terpenoid constituents in both LFME and NBF-LFME. Accordingly, we conclude that NBF-LFME is the most potent fraction producing a concentration-dependent relaxation in vascular smooth muscle in vitro and a dose-dependent blood pressure lowering activity in vivo. The cardiovascular effects of NBF-LFME are most likely attributable to its terpenoid content.
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Full text: Available Index: LILACS (Americas) Main subject: Vasodilation / Blood Pressure / Plant Extracts / 1-Butanol / Loranthaceae / Muscle, Smooth, Vascular Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2010 Type: Article Affiliation country: Malaysia Institution/Affiliation country: Universiti Sains Malaysia/MY

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Full text: Available Index: LILACS (Americas) Main subject: Vasodilation / Blood Pressure / Plant Extracts / 1-Butanol / Loranthaceae / Muscle, Smooth, Vascular Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2010 Type: Article Affiliation country: Malaysia Institution/Affiliation country: Universiti Sains Malaysia/MY