Antimycobacterial neolignans isolated from Aristolochia taliscana
Mem. Inst. Oswaldo Cruz
;
105(1): 45-51, Feb. 2010. tab, ilus
Article
in English
| LILACS
| ID: lil-539295
ABSTRACT
Tuberculosis (TB - Mycobacterium tuberculosis) is an ancient infectious disease that has appeared once again as a serious worldwide health problem and now comprises the second leading cause of death resulting from a single infection. The prevalence of multidrug resistance (MDR) TB is increasing and therapeutic options for treatment are not always accessible; in fact, some patients do not respond to the available drugs. Therefore, there is an urgent need to develop novel anti-TB agents. The aim of the present study was to screen extracts of Aristolochia taliscana, a plant used in traditional Mexican medicine to treat cough and snake bites, for antimycobacterial activity. The hexanic extract of A. taliscana was tested by microdilution alamar blue assay against Mycobacterium strains and bioguided fractionation led to the isolation of the neolignans licarin A, licarin B and eupomatenoid-7, all of which had antimycobacterial activity. Licarin A was the most active compound, with minimum inhibitory concentrations of 3.12-12.5 ìg/mL against the following M. tuberculosis strains H37Rv, four mono-resistant H37Rv variants and 12 clinical MDR isolates, as well as against five non-tuberculous mycobacteria (NTM) strains. In conclusion, licarin A represents a potentially active anti-TB agent to treat MDR M. tuberculosis and NTM strains.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Plant Extracts
/
Lignans
/
Aristolochia
/
Anti-Bacterial Agents
/
Mycobacterium tuberculosis
Type of study:
Risk factors
Limits:
Humans
Country/Region as subject:
Mexico
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2010
Type:
Article
/
Project document
Affiliation country:
Mexico
Institution/Affiliation country:
Centro Médico Nacional Siglo XXI/MX
/
Instituto Mexicano del Seguro Social/MX
/
Instituto Politécnico Nacional/MX
/
Unidad Investigación Médica en Farmacología de Productos Naturales/MX
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