Your browser doesn't support javascript.
loading
Antimycobacterial neolignans isolated from Aristolochia taliscana
León-Díaz, Rosalba; Meckes, Mariana; Said-Fernández, Salvador; Molina-Salinas, Gloria Maria; Vargas-Villarreal, Javier; Torres, Javier; Luna-Herrera, Julieta; Jiménez-Arellanes, Adelina.
  • León-Díaz, Rosalba; Unidad Investigación Médica en Farmacología de Productos Naturales. MX
  • Meckes, Mariana; Unidad Investigación Médica en Farmacología de Productos Naturales. MX
  • Said-Fernández, Salvador; Instituto Mexicano del Seguro Social. Centro de Investigacion Biomedica del Noroeste. División de Biologia Celular y Molecular. Nuevo Leon. MX
  • Molina-Salinas, Gloria Maria; Instituto Mexicano del Seguro Social. Centro de Investigacion Biomedica del Noroeste. División de Biologia Celular y Molecular. Nuevo Leon. MX
  • Vargas-Villarreal, Javier; Instituto Mexicano del Seguro Social. Centro de Investigacion Biomedica del Noroeste. División de Biologia Celular y Molecular. Nuevo Leon. MX
  • Torres, Javier; Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social. Hospital de Pediatría. Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias. México DF. MX
  • Luna-Herrera, Julieta; Instituto Politécnico Nacional. Escuela Nacional de Ciencias Biológicas. Departamento de Inmunoquímica. Laboratorio de Inmunoquímica II. México DF. MX
  • Jiménez-Arellanes, Adelina; Unidad Investigación Médica en Farmacología de Productos Naturales. MX
Mem. Inst. Oswaldo Cruz ; 105(1): 45-51, Feb. 2010. tab, ilus
Article in English | LILACS | ID: lil-539295
ABSTRACT
Tuberculosis (TB - Mycobacterium tuberculosis) is an ancient infectious disease that has appeared once again as a serious worldwide health problem and now comprises the second leading cause of death resulting from a single infection. The prevalence of multidrug resistance (MDR) TB is increasing and therapeutic options for treatment are not always accessible; in fact, some patients do not respond to the available drugs. Therefore, there is an urgent need to develop novel anti-TB agents. The aim of the present study was to screen extracts of Aristolochia taliscana, a plant used in traditional Mexican medicine to treat cough and snake bites, for antimycobacterial activity. The hexanic extract of A. taliscana was tested by microdilution alamar blue assay against Mycobacterium strains and bioguided fractionation led to the isolation of the neolignans licarin A, licarin B and eupomatenoid-7, all of which had antimycobacterial activity. Licarin A was the most active compound, with minimum inhibitory concentrations of 3.12-12.5 ìg/mL against the following M. tuberculosis strains H37Rv, four mono-resistant H37Rv variants and 12 clinical MDR isolates, as well as against five non-tuberculous mycobacteria (NTM) strains. In conclusion, licarin A represents a potentially active anti-TB agent to treat MDR M. tuberculosis and NTM strains.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Plant Extracts / Lignans / Aristolochia / Anti-Bacterial Agents / Mycobacterium tuberculosis Type of study: Risk factors Limits: Humans Country/Region as subject: Mexico Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2010 Type: Article / Project document Affiliation country: Mexico Institution/Affiliation country: Centro Médico Nacional Siglo XXI/MX / Instituto Mexicano del Seguro Social/MX / Instituto Politécnico Nacional/MX / Unidad Investigación Médica en Farmacología de Productos Naturales/MX

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: LILACS (Americas) Main subject: Plant Extracts / Lignans / Aristolochia / Anti-Bacterial Agents / Mycobacterium tuberculosis Type of study: Risk factors Limits: Humans Country/Region as subject: Mexico Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2010 Type: Article / Project document Affiliation country: Mexico Institution/Affiliation country: Centro Médico Nacional Siglo XXI/MX / Instituto Mexicano del Seguro Social/MX / Instituto Politécnico Nacional/MX / Unidad Investigación Médica en Farmacología de Productos Naturales/MX