Your browser doesn't support javascript.
loading
Serum total IgE levels and total eosinophil counts: relationship with treatment response in patients with acute asthma / Relação dos níveis séricos de IgE total e das contagens de eosinófilos com a resposta ao tratamento em pacientes com asma aguda
Razi, Ebrahim; Moosavi, Gholam Abbass.
  • Razi, Ebrahim; Kashan University of Medical Sciences. Kashan. IR
  • Moosavi, Gholam Abbass; Kashan University of Medical Sciences. Kashan. IR
J. bras. pneumol ; 36(1): 23-28, jan.-fev. 2010. tab
Article in English | LILACS | ID: lil-539431
ABSTRACT

OBJECTIVE:

To determine whether serum total IgE levels and total eosinophil counts have any relationship with the response to routine pharmacological treatment in patients with acute asthma.

METHODS:

A cross-sectional study involving 162 patients with acute asthma. Serum total IgE levels, peripheral blood cell counts and eosinophil counts were determined. The treatment was adjusted for each patient according to the severity of asthma. Spirometry was performed at baseline and two weeks after the treatment. The patients were divided into two groups high IgE (>100 IU/mL) and low IgE (<100 IU/mL). We compared the two groups in terms of the relationships between baseline values and final values (percentage change) for the following parameters FEV1, FVC, FEF25-75 percent, peripheral white blood cell counts and eosinophil counts.

RESULTS:

There were no significant differences between the groups regarding the percentage changes of the studied parameters. Nor were there significant differences between the groups regarding FEV1, FVC, and FEF25-75 percent ( percent of the predicted values) at baseline.

CONCLUSIONS:

On the basis of these findings, we conclude that serum total IgE levels, peripheral white blood cell counts and eosinophil counts cannot predict the response to the pharmacological treatment of patients with acute asthma.
RESUMO

OBJETIVO:

Determinar se há uma relação dos níveis de IgE total no soro e das contagens de eosinófilos com a resposta à farmacoterapia de rotina em pacientes com asma aguda.

MÉTODOS:

Estudo transversal com 162 pacientes com asma aguda. Foram determinados os níveis séricos de IgE total, as contagens de células no sangue periférico e as contagens de eosinófilos. O tratamento foi ajustado individualmente de acordo com a gravidade da asma. Foi realizada espirometria antes do início do tratamento e duas semanas após seu término. Os pacientes foram divididos em dois grupos alto nível de IgE (> 100 UI/mL) e baixo nível de IgE (< 100 UI/mL). Foram comparadas entre os dois grupos as relações das determinações basais e das alterações em percentual dos seguintes parâmetros VEF, CVF, FEF25-75 por cento, contagem de células brancas no sangue periférico e contagem de eosinófilos.

RESULTADOS:

Não houve diferenças significativas entre os grupos em relação às alterações em percentual dos parâmetros estudados. Tampouco houve diferenças significativas entre os grupos em relação aos valores basais de VEF, CVF e FEF25-75 por cento, em por cento do predito.

CONCLUSÕES:

Com base nesses achados, concluímos que os níveis séricos de IgE total, as contagens de células brancas no sangue periférico e as contagens de eosinófilos não são preditores do tratamento farmacológico de pacientes com asma aguda.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Asthma / Immunoglobulin E / Eosinophils Type of study: Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: J. bras. pneumol Journal subject: Pulmonary Disease (Specialty) Year: 2010 Type: Article Affiliation country: Iran Institution/Affiliation country: Kashan University of Medical Sciences/IR

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: LILACS (Americas) Main subject: Asthma / Immunoglobulin E / Eosinophils Type of study: Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: J. bras. pneumol Journal subject: Pulmonary Disease (Specialty) Year: 2010 Type: Article Affiliation country: Iran Institution/Affiliation country: Kashan University of Medical Sciences/IR