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ApoE polymorphisms and diarrheal outcomes in Brazilian shanty town children
Oriá, R. B; Patrick, P. D; Oriá, M. O. B; Lorntz, B; Thompson, M. R; Azevedo, O. G. R; Lobo, R. N. B; Pinkerton, R. F; Guerrant, R. L; Lima, A. A. M.
  • Oriá, R. B; Universidade Federal do Ceará. Departamento de Morfologia. Fortaleza. BR
  • Patrick, P. D; University of Virginia. Kluge Children's Rehabilitation and Research Center. Charlottesville. US
  • Oriá, M. O. B; Universidade Federal do Ceará. Departamento de Enfermagem. Fortaleza. BR
  • Lorntz, B; Universidade Federal do Ceará. Faculdade de Medicina. Instituto de Biomedicina do Semi-árido Brasileiro. Fortaleza. BR
  • Thompson, M. R; School of Medicine. Center for Global Health. US
  • Azevedo, O. G. R; Universidade Federal do Ceará. Faculdade de Medicina. Instituto de Biomedicina do Semi-árido Brasileiro. Fortaleza. BR
  • Lobo, R. N. B; Centro de Pesquisa da EMPRAPA. Sobral. BR
  • Pinkerton, R. F; School of Medicine. Center for Global Health. US
  • Guerrant, R. L; School of Medicine. Center for Global Health. US
  • Lima, A. A. M; School of Medicine. Center for Global Health. US
Braz. j. med. biol. res ; 43(3): 249-256, Mar. 2010. tab, graf
Article in English | LILACS | ID: lil-539712
ABSTRACT
A series of studies have shown that the heavy burdens of diarrheal diseases in the first 2 formative years of life in children living in urban shanty towns have negative effects on physical and cognitive development lasting into later childhood. We have shown that APOE4 is relatively common in shanty town children living in Brazil (13.4 percent) and suggest that APOE4 has a protective role in cognitive development as well as weight-for-height in children with heavy burdens of diarrhea in early childhood (64/123; 52 percent), despite being a marker for cognitive decline with Alzheimer’s and cardiovascular diseases later in life. APOE2 frequency was higher among children with heaviest diarrhea burdens during the first 2 years of life, as detected by PCR using the restriction fragment length polymorphism method, raising the possibility that ApoE-cholesterol balance might be critical for growth and cognitive development under the stress of heavy diarrhea burdens and when an enriched fat diet is insufficient. These findings provide a potential explanation for the survival advantage in evolution of genes, which might raise cholesterol levels during heavy stress of diarrhea burdens and malnutrition early in life.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Apolipoproteins E / Polymorphism, Genetic / Diarrhea, Infantile Type of study: Etiology study / Incidence study / Observational study / Risk factors Limits: Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2010 Type: Article Affiliation country: Brazil / United States Institution/Affiliation country: Centro de Pesquisa da EMPRAPA/BR / School of Medicine/US / Universidade Federal do Ceará/BR / University of Virginia/US

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Full text: Available Index: LILACS (Americas) Main subject: Apolipoproteins E / Polymorphism, Genetic / Diarrhea, Infantile Type of study: Etiology study / Incidence study / Observational study / Risk factors Limits: Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2010 Type: Article Affiliation country: Brazil / United States Institution/Affiliation country: Centro de Pesquisa da EMPRAPA/BR / School of Medicine/US / Universidade Federal do Ceará/BR / University of Virginia/US