Cell migration induced by Leishmania (Leishmania) amazonensis, Leishmania (Leishmania) major and Leishmania (Viannia) braziliensis into the peritoneal cavity of BALB/c mice
J. venom. anim. toxins incl. trop. dis
;
16(1): 170-177, 2010. tab
Article
in English
| LILACS
| ID: lil-542427
ABSTRACT
In American cutaneous leishmaniasis, the initial infection phase is characterized by recruitment of neutrophils and monocytes. The migration of these cells in response to the presence of Leishmania in the peritoneum of affected animals remains unclear. The objective of this study was to investigate cell migration to the peritoneum of BALB/c mice after infection with Leishmania (Leishmania) amazonensis, Leishmania (Viannia) braziliensis and Leishmania (Leishmania) major. Initially, Leishmania spp. was intraperitoneally inoculated in five groups of six animals each and the cell migration was analyzed 0, 3, 6, 12, 24 and 48 hours after infection. Different cell counts were performed with a staining kit and showed a higher percentage of polymorphonuclear than mononuclear cells in all three species studied. The total cell count revealed peak migration in L. (L.) amazonensis and L. (L.) major at six hours, and in L. (V.) braziliensis at 12 hours. These results suggest that factors released from different cell types probably act by attracting polymorphonuclear cells, with the peak migration most likely depending on the species of Leishmania inoculated into the host.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Peritoneal Cavity
/
Leishmania braziliensis
/
Cell Movement
/
Leishmaniasis, Cutaneous
/
Leishmania major
/
Mice, Inbred BALB C
Limits:
Animals
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
J. venom. anim. toxins incl. trop. dis
Journal subject:
Toxicology
Year:
2010
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
State University of Maringá/BR
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