Contribuição do LACEN-MS no diagnóstico da tuberculose e da resistência às drogas antituberculosas em Mato Grosso do Sul / The contribution of the Public Health Central Laboratory of Mato Grosso do Sul to the diagnosis
Rev. bras. anal. clin
;
41(3): 191-196, 2009. tab, graf
Article
in Portuguese
| LILACS
| ID: lil-544440
RESUMO
Com a disseminacao da AIDS e o surgimento de cepas de Mycobacterium tuberculosis resistentes a quimioterapicos, a tuberculosetem recrudescido mundialmente. Avaliar a demanda ao Laboratorio Central de Mato Grosso do Sul (LACEN-MS) por diagnostico de M. tuberculosis e a prevalencia da resistencia a drogas antituberculose entre casos notificados ao SINAN em 2000-2006. Estudo descritivo de dados de cultivo e de testes de sensibilidade (com metodo das proporcoes) a rifampicina, isoniazida, estreptomicina e etambutol de casos notificados. Materiais biologicos (pulmonares e/ou extrapulmonares) de casos suspeitos foram semeados emmeios LowensteinJensen e OgawaKudoh e no sistema automatizado Bactec MGIT 960. No periodo, 66 dos 78 municipios enviaram 18 392 amostras, sendo 2 009 (10,9%) positivas. Em 1 174 (58,4%) destas realizou-se TS. Selecionaram-se 783 (66,7%) para o levantamento de resistencia, sendo 645 (82,4%) de casos nunca tratados e 138 (17,6%) com registro de tratamento. Constatou-se resistencia primaria, adquirida e combinada em 12,4%, 45,7% e 18,3% dos casos, respectivamente. O LACEN-MS atendeu 84,6% dos municipios. Entre os casos notificados ao SINAN verificou-se alta resistencia, com tuberculose multirresistente adquirida em 20,3%, evidenciando o uso previo de medicamentos como indicador de resistencia.
ABSTRACT
With the spread of AIDS and the emergence of drug-resistant Mycobacterium tuberculosis strains, tuberculosis has made a vigorous comeback worldwide. To evaluate the demands placed on the Public Health Central Laboratory of the State of MatoGrosso do Sul (LACEN-MS) for the diagnosis of M. tuberculosis and to determine the prevalence of antituberculosis drug resistanceamong cases notified to the Brazilian Information System of Notifiable Hazards (SINAN) in 2000-2006. A descriptive study of the results of culture tests and of sensitivity tests performed for rifampicin, isoniazid, streptomycin, and ethambutol (proportion method) on material from notified cases. Pulmonary and/or extrapulmonary materials from suspected cases were seeded on LõwensteinJensen and OgawaKudoh. The Bactec MGIT 960 automated system was used. In the period investigated, 18 392 samples referred by 66 of the 78 counties in Mato Grosso do Sul were analyzed, 2 009 (10.9%) of which were positive. Sensitivity tests were performed on 1 174 (58.4%) of these. Resistance was investigated in 783 (66.7%) cases, of which 645 (82.4%) were naive to treatment and 138 (17.6%) had been previously treated. Primary, acquired, and combined resistance were found in 12.4%, 45.7%, and 18.3% of cases, respectively. LACEN-MS served 84.6% of Mato Grosso do Suls counties. Acquired multidrug resistance was found in 20.3% of the notified cases,demonstrating that previous use of drug therapy can be viewed as an indicator of resistance.
Full text:
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Index:
LILACS (Americas)
Main subject:
Tuberculosis, Pulmonary
/
Drug Resistance
/
Microbial Sensitivity Tests
/
Prevalence
/
Tuberculosis, Multidrug-Resistant
/
Mycobacterium tuberculosis
Type of study:
Diagnostic study
/
Prevalence study
/
Risk factors
Limits:
Humans
Language:
Portuguese
Journal:
Rev. bras. anal. clin
Journal subject:
Pathology
Year:
2009
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Laboratório Central de Saúde Pública de Mato Grosso do Sul/BR
/
Secretaria de Estado de Saúde de Mato Grosso do Sul/BR
/
UNESP/BR
/
Universidade Federal de Mato Grosso do Sul/BR
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