A coinfecção tuberculose e HIV: um importante desafio - Artigo de revisão / The coinfection HIV/tuberculosis: a important challenge - A review

RESUMO

A imunodeficiencia adquirida (SIDA) levou ao ressurgimento da tuberculose. A infeccao pelo virus da imunodeficiencia(HIV) e o Mycobacterium tuberculosis tem interacao sinergica, um acentuando a progressao do outro. Em individuos com estagio avancado de imunodeficiencia a tuberculose pode se apresentar de forma atipica, dificultando seu diagnostico, aumentando sua incidencia, agravando o panorama desta infeccao na saude publica. O tratamento da tuberculose e complicado devido interacao medicamentosa com a terapia antirretroviral. Todos estes fatores ressaltam a importancia desta revisao da literatura.

ABSTRACT

The acquired immunodeficiency syndrome (AIDS) causes the resurgence of tuberculosis. The HIV and Mycobacterium tuberculosis have a synergistic interaction; each accentuates progression of the other. In late HIV infection, tuberculosis is often atypical in presentation, with difficult diagnosis. These features enhance the incidence rates of TB, with catastrophic impact on public health. Antituberculosis treatment is complicated by frequent drug-interactions with highly active antirretroviral therapy. All this factorsincrease the importance of a literature review.