Clinical presentation of leptospirosis: a retrospective study of 201 patients in a metropolitan city of Brazil
Braz. j. infect. dis
;
14(1): 03-10, Jan.-Feb. 2010. tab, ilus
Article
in English
| LILACS
| ID: lil-544999
ABSTRACT
INTRODUCTION:
leptospirosis is a zoonosis of worldwide importance. The disease is endemic in Brazil. This study was conducted to describe the clinical and laboratory presentation of leptospirosis in a metropolitan city of Brazil.METHODS:
this is a retrospective study including 201 consecutive patients with leptospirosis admitted to tertiary hospitals in Fortaleza, Brazil, between 1985 and 2006. All patients had clinical and epidemiological data suggestive of leptospirosis, and positive laboratorial test for leptospirosis (microscopic agglutination test, MAT, higher than 1800).RESULTS:
a total of 201 patients were included, with mean age of 38.9 ± 15.7 years; 79.1 percent were male. The mean length from onset of symptoms to admission was 7 ± 3 days. The main clinical signs and symptoms at admission were fever (96.5 percent), jaundice (94.5 percent), myalgia (92.5 percent), headache (74.6 percent), vomiting (71.6 percent) and dehydration (63.5 percent). Hemorrhagic manifestations were present in 35.8 percent. Acute kidney injury was found in 87 percent of the patients. Platelet count was less than 100,000/mm³ in 74.3 percent. Hematuria was found in 42.9 percent. Death occurred in 31 cases (15.4 percent).CONCLUSIONS:
leptospirosis is a globally relevant disease with potential fatal outcome. Signs and symptoms suggestive of leptospirosis must be known by any physician in order to institute early adequate treatment to improve outcome. Early indication and daily hemodialysis seems to be beneficial in this group of patients.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Leptospirosis
Type of study:
Diagnostic study
/
Observational study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2010
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal do Ceará/BR
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