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Antifungal susceptibility profile of trichosporon isolates: correlation between CLSI and etest methodologies
Lemes, Raquel M. L; Lyon, Juliana P; Moreira, Leonardo M; Resende, Maria Aparecida de.
  • Lemes, Raquel M. L; Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte. BR
  • Lyon, Juliana P; Universidade do Vale do Paraíba. Instituto de Pesquisa e Desenvolvimento. São José dos Campos. BR
  • Moreira, Leonardo M; Universidade Federal de São João Del Rei. Departamento de Engenharia Biomédica. São João Del Rei. BR
  • Resende, Maria Aparecida de; Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte. BR
Braz. j. microbiol ; 41(2): 310-315, Apr.-June 2010. tab
Article in English | LILACS | ID: lil-545335
ABSTRACT
The aim of the present study was to evaluate the antifungal susceptibility profile of Trichosporon species isolated from different sources employing the Clinical and Laboratory Standards Institute (CLSI) method and E-test method. Thirty-four isolates of Trichosporon spp. and six CBS reference samples were tested for their susceptibility to Amphotericin B, 5-flucytosine, Fluconazole, Itraconazole, Voriconazole and Terbinafine. All species showed high Minimun Inhibitory Concentrations (MIC) for Itraconazole and susceptibility to Fluconazole, The comparison among the results obtained by the CLSI method and E-test revealed larger discrepancies among 5-flucytosine and Itraconazole. The present work provides epidemiological data that could influence therapeutic choices. Furthermore, the comparison between different methodologies could help to analyze results obtained by different laboratories.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Trichosporon / Drug Resistance, Fungal / Mitosporic Fungi / Disease Susceptibility / Mycoses / Antifungal Agents Type of study: Practice guideline Limits: Humans Language: English Journal: Braz. j. microbiol Journal subject: Microbiology Year: 2010 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Minas Gerais/BR / Universidade Federal de São João Del Rei/BR / Universidade do Vale do Paraíba/BR

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Full text: Available Index: LILACS (Americas) Main subject: Trichosporon / Drug Resistance, Fungal / Mitosporic Fungi / Disease Susceptibility / Mycoses / Antifungal Agents Type of study: Practice guideline Limits: Humans Language: English Journal: Braz. j. microbiol Journal subject: Microbiology Year: 2010 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Minas Gerais/BR / Universidade Federal de São João Del Rei/BR / Universidade do Vale do Paraíba/BR