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Limitations in differentiating vascular dementia from Alzheimer's disease with brief cognitive tests / Limitações em diferenciar demência vascular de doença de Alzheimer através de testes cognitivos breves
Matioli, Maria Niures P. S; Caramelli, Paulo.
  • Matioli, Maria Niures P. S; Lusíada University School of Medicine. Department of Geriatrics. Santos. BR
  • Caramelli, Paulo; University of São Paulo School of Medicine. Department of Neurology. São Paulo. BR
Arq. neuropsiquiatr ; 68(2): 185-188, Apr. 2010. tab
Article in English | LILACS | ID: lil-545913
ABSTRACT

OBJECTIVE:

To investigate the diagnostic value of brief cognitive tests in differentiating vascular dementia (VaD) from Alzheimer's disease (AD).

METHOD:

Fifteen patients with mild VaD, 15 patients with mild probable AD and 30 healthy controls, matched for age, education and dementia severity, were submitted to the following cognitive tests clock drawing (free drawing and copy), category and letter fluency, delayed recall test of figures and the EXIT 25 battery.

RESULTS:

VaD patients performed worse than AD patients in category fluency (p=0.014), letter fluency (p=0.043) and CLOX 2 (p=0.023), while AD cases performed worse than VaD patients in delayed recall (p=0.013). However, ROC curves for these tests displayed low sensitivity and specificity for the differential diagnosis between VaD and AD.

CONCLUSION:

Although the performance of VaD and AD patients was significantly different in some cognitive tests, the value of such instruments in differentiating VaD from AD proved to be very limited.
RESUMO

OBJETIVO:

Investigar o valor diagnóstico de testes cognitivos breves na diferenciação de demência vascular (DV) e doença de Alzheimer (DA).

MÉTODO:

Quinze pacientes com DV, 15 com DA provável e 30 controles saudáveis, pareados em relação à idade, escolaridade e gravidade da demência, foram submetidos aos seguintes testes desenho do relógio espontâneo e cópia, fluência verbal semântica e fonêmica, teste de evocação de memória de figuras e a bateria EXIT25.

RESULTADOS:

Pacientes com DV apresentaram pior desempenho na fluência verbal semântica (p=0,014), fonêmica (p=0,043), e no CLOX 2 (p=0,023). O grupo com DA obteve pior desempenho no teste de evocação tardia (p=0,013). As curvas ROC aplicadas a esses testes mostraram baixa sensibilidade e especificidade para o diagnóstico diferencial entre DV e DA.

CONCLUSÃO:

Embora o desempenho dos pacientes tenha sido diferente em alguns testes, o valor desses instrumentos para o diagnóstico diferencial entre DV e DA parece ser muito limitado.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Dementia, Vascular / Alzheimer Disease / Neuropsychological Tests Type of study: Diagnostic study / Observational study / Risk factors Limits: Aged / Female / Humans / Male Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2010 Type: Article Affiliation country: Brazil Institution/Affiliation country: Lusíada University School of Medicine/BR / University of São Paulo School of Medicine/BR

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Full text: Available Index: LILACS (Americas) Main subject: Dementia, Vascular / Alzheimer Disease / Neuropsychological Tests Type of study: Diagnostic study / Observational study / Risk factors Limits: Aged / Female / Humans / Male Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2010 Type: Article Affiliation country: Brazil Institution/Affiliation country: Lusíada University School of Medicine/BR / University of São Paulo School of Medicine/BR