Brain SPECT in mesial temporal lobe epilepsy: comparison between visual analysis and SPM / SPECT cerebral na epilepsia de lobo temporal mesial: comparação entre análise visual e SPM
Arq. neuropsiquiatr
;
68(2): 153-160, Apr. 2010. tab, ilus
Article
in English
| LILACS
| ID: lil-545938
ABSTRACT
OBJECTIVE:
To compare the accuracy of SPM and visual analysis of brain SPECT in patients with mesial temporal lobe epilepsy (MTLE).METHOD:
Interictal and ictal SPECTs of 22 patients with MTLE were performed. Visual analysis were performed in interictal (VISUAL(inter)) and ictal (VISUAL(ictal/inter)) studies. SPM analysis consisted of comparing interictal (SPM(inter)) and ictal SPECTs (SPM(ictal)) of each patient to control group and by comparing perfusion of temporal lobes in ictal and interictal studies among themselves (SPM(ictal/inter)).RESULTS:
For detection of the epileptogenic focus, the sensitivities were as follows VISUAL(inter)=68 percent; VISUAL(ictal/inter)=100 percent; SPM(inter)=45 percent; SPM(ictal)=64 percent and SPM(ictal/inter)=77 percent. SPM was able to detect more areas of hyperperfusion and hypoperfusion.CONCLUSION:
SPM did not improve the sensitivity to detect epileptogenic focus. However, SPM detected different regions of hypoperfusion and hyperperfusion and is therefore a helpful tool for better understand pathophysiology of seizures in MTLE.RESUMO
OBJETIVO:
Comparar a acurácia do SPM com a análise visual na detecção do foco epileptogênico e alterações perfusionais à distância no SPECT cerebral.MÉTODO:
Foram realizados os SPECTs ictal e interictal de 22 pacientes com epilepsia de lobo temporal mesial (ELTM). A análise visual foi realizada nos estudos interictal (VISUAL(inter)) e ictal (VISUAL(ictal/inter)). Na análise com SPM foi comparado o estudo interictal (SPM(inter)) e ictal (SPM(ictal)) de cada paciente com o grupo controle e comparou-se a perfusão dos lobos temporais entre os estudos ictal e interictal (SPM(ictal/inter)).RESULTADOS:
Para a detecção do foco epileptogênico, as sensibilidades foram as seguintes VISUAL(inter)=68 por cento; VISUAL(ictal/inter)=100 por cento; SPM(inter)=45 por cento; SPM(ictal)=64 por cento and SPM(ictal/inter)=77 por cento. O SPM foi capaz de detectar mais áreas de hiperperfusão e hipoperfusão.CONCLUSÃO:
O SPM não aumentou a sensibilidade na detecção do foco epileptogênico. Entretanto, o SPM detectou diferentes regiões de hipoperfusão e hiperperfusão e portanto, ele pode ser uma ferramenta de ajuda para se melhor entender a patofisiologia das crises na ELTM.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Brain Mapping
/
Tomography, Emission-Computed, Single-Photon
/
Epilepsy, Temporal Lobe
Type of study:
Observational study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Arq. neuropsiquiatr
Journal subject:
Neurology
/
Psychiatry
Year:
2010
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Campinas State University/BR
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