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Manipulación del transporte y consumo de oxígeno en la sepsis / Management of oxygen delivery and consumption during sepsis
Regueria, Tomas; Andresen, Max.
  • Regueria, Tomas; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Medicina Intensiva. Santiago. CL
  • Andresen, Max; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Medicina Intensiva. Santiago. CL
Rev. méd. Chile ; 138(2): 233-242, feb. 2010. tab, ilus
Article in Spanish | LILACS | ID: lil-546217
ABSTRACT
Maintaining an adequate tissue oxygen delivery (DO) and consumption (VO) is crucial in the treatment of septic patients. A fall in V02 is associated with a higher mortality. The early recognition of shock or tissue hypo perfusion impacts on patient prognosis. In occasions, hypovolemia or important regional oxygen debts are not recognized, since macro homodynamic variables have been compensated. In this situation, the use of metabolic hypo perfusion markers such as lactate, central venous oxygen saturation and gastric goniometry, can be helpful. However, interpretation of these markers should be cautious and always considering the overall clinical status of the patient. In the initial stages of sepsis, the dependency ofV02 on DO 2predominates as histopathological mechanism of multiple organic failure. In late stages, other factors predominate as determinants of multiple organic failure and mortality, such as hyper or hypo immune response, microcirculatory alterations and cytopathic hypoxia.
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Full text: Available Index: LILACS (Americas) Main subject: Oxygen / Oxygen Consumption / Sepsis Type of study: Diagnostic study / Prognostic study Limits: Animals / Humans Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2010 Type: Article Affiliation country: Chile Institution/Affiliation country: Pontificia Universidad Católica de Chile/CL

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Full text: Available Index: LILACS (Americas) Main subject: Oxygen / Oxygen Consumption / Sepsis Type of study: Diagnostic study / Prognostic study Limits: Animals / Humans Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2010 Type: Article Affiliation country: Chile Institution/Affiliation country: Pontificia Universidad Católica de Chile/CL