Sospechas de reacciones adversas a medicamentos en Servicios de Terapia / Suspicions of adverse drug reactions at the Therapy Services
Rev. cuba. med. mil
;
37(4)oct.-dic. 2008.
Article
in Spanish
| LILACS
| ID: lil-547119
RESUMEN
INTRODUCCIÓN:
La farmacovigilancia es la disciplina científica imprescindible para afrontar los problemas que plantea un arsenal de medicamentos que no deja de crecer en variedad y potencia.OBJETIVO:
Caracterizar las sospechas de reacciones adversas a medicamentos en Servicios de Terapia del Instituto Superior de Medicina Militar Dr. Luis Díaz Soto.MÉTODOS:
Se realizó un estudio descriptivo, prospectivo que incluyó todos los pacientes ingresados durante un mes, que fueron monitorizados diariamente mediante interrogatorios farmacológicos, pases de visita y revisión de Historias Clínicas.RESULTADOS:
De 206 pacientes, 21 presentaron sospechas de reacciones adversas a medicamentos (10,2 por ciento); la Unidad de Cuidados Especiales del Cuerpo de Guardia y la Terapia Intermedia de Cirugía resultaron los de mayores porcentajes (15,0 y 11,7 por ciento por ciento). Las manifestaciones clínicas mßs frecuentes se relacionaron con el rash cutáneo, cefalea y náuseas (12,5 por ciento). Predominaron los pacientes de 60 años y más (47,6 por ciento) y del sexo femenino (71,4 por ciento). Los antimicrobianos fueron los más reportados con 33,3 por ciento, seguidos de los analgésicos, antipiréticos y antiinflamatorios (23,8 por ciento). Existió un predominio de las sospechas de reacciones adversas a medicamentos del sistema nervioso central y periférico (28,1 por ciento), seguidos del sistema gastrointestinal (25,0 por ciento) y de piel (21,8 por ciento). Prevalecieron las sospechas de reacciones adversas a medicamentos de severidad moderada (52,3 por ciento), y al analizar la relación medicamentos-sospechas de reacciones adversas a medicamentos se obtuvo una superioridad de las probables (52,3 por ciento).CONCLUSIONES:
La aparición de sospechas de reacciones adversas a medicamentos en los Servicios de Terapia es considerable. Los antimicrobianos aportaron el mayor porcentaje de sospechas de reacciones adversas a medicamentos. El sistema...ABSTRACT
INTRODUCTION:
Pharmacosurveillance is the indispensable scientific discipline to face the problems of a group of drugs increasingly growing in variety and potency.OBJECTIVES:
To characterize the suspicions of adverse reactions to drugs in the Therapy Service of Dr.Luís Díaz Soto Higher Institute of Military Medicine.METHODS:
We made a prospective and descriptive study including all patients admitted during a month that were daily monitored by means of pharmacological questionnaries, medical rounds, and review of medical histories.RESULTS:
Of 206 patients, 21 had suspicions of adverse reactions to drugs (10.2 percent). The Special Care Unit (SCU) of the Emergency Department, and the Surgery Intermediate Therapy Unit showed the greatest percentages (15.0 and 11.7 percent). The most frequent clinical manifestations were related to skin rash, headache, and nausea (12.5 percent). There was a predominance of patients aged 60 and over (47.6 percent) and of females (71.4 percent). The antimicrobial agents were the most reported with a 33.3 percent, followed by analgesics, antipyretics, and anti-inflammatory agents (23.8 percent). It was observed a prevalence of suspicions of adverse reactions to drugs of the central and peripheral nervous system (28.1 percent), followed by the gastrointestinal system (25.0 percent), and skin (21.8 percent). The suspicions of adverse reactions of moderate severity to drugs prevailed (52.3 percent). On analyzing the drugs/suspicions of adverse drug reactions ratio, we found a superiority of the probable ones (52.3 percent).CONCLUSIONS:
The appearance of suspicions of adverse reactions to drugs in the Therapy Service is significant. The antimicrobial agents presented the highest percentage of suspicions of adverse reactions to drugs. The central and peripheral nervous system was the most affected, and the suspicions of moderate adverse reactions to drugs were greater, with a predominance of those...
Full text:
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Index:
LILACS (Americas)
Main subject:
Pharmaceutical Preparations
/
Intensive Care Units
Type of study:
Observational study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. cuba. med. mil
Journal subject:
History of Medicine
/
Military Medicine
Year:
2008
Type:
Article
Affiliation country:
Cuba
Institution/Affiliation country:
Instituto Superior de Medicina Militar Dr. Luis Díaz Soto/CU
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