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Endemic hepatitis b and c virus infection in a brazilian eastern amazon region
El Khouri, Marcelo; Cordeiro, Quirino; Luz, Diogo Arantes Behling Pereira da; Duarte, Leandro Savoy; Gama, Mônica Elinor Alves; Corbett, Carlos Eduardo Pereira.
  • El Khouri, Marcelo; University of São Paulo. Medical School. Laboratory of Infectious Diseases Pathology. São Paulo. BR
  • Cordeiro, Quirino; University of São Paulo. Medical School. Laboratory of Infectious Diseases Pathology. São Paulo. BR
  • Luz, Diogo Arantes Behling Pereira da; University of São Paulo. Medical School. Laboratory of Infectious Diseases Pathology. São Paulo. BR
  • Duarte, Leandro Savoy; University of São Paulo. Medical School. Laboratory of Infectious Diseases Pathology. São Paulo. BR
  • Gama, Mônica Elinor Alves; Federal University of Maranhão Medical School. Center of Health Sciences. São Luís. BR
  • Corbett, Carlos Eduardo Pereira; University of São Paulo. Medical School. Laboratory of Infectious Diseases Pathology. São Paulo. BR
Arq. gastroenterol ; 47(1): 35-41, Jan.-Mar. 2010. tab
Article in English | LILACS | ID: lil-547611
ABSTRACT
CONTEXT Hepatitis B and hepatitis C infection has been an important cause of morbidity and mortality around the world. However there are few investigations regarding the prevalence and possible risk factors for these diseases in Brazil, particularly in Amazon region, where there are some endemic focus.

OBJECTIVES:

To determine the prevalence of hepatitis B and hepatitis C in the city of Buriticupu, MA, located in the Brazilian Eastern Amazon region, and try to explore the risk factors for these infections in that area.

METHODS:

Two hundred forty three subjects (46.5 percent male and 53.5 percent female) were investigated.

RESULTS:

The prevalence of past or current infection of hepatitis B and C virus was, respectively, 40.74 percent and 5.76 percent. Positivity for HBsAg was found in 2.88 percent of the subjects. The prevalence of current infection or chronic virus carriers found was 2.88 percent (HBsAg). There was a statistically significant relationship between the sera-prevalence of anti-HBc and the distance of the residence from the city center which may reflect an indirect association between the infection and precarious conditions of existence. Individuals with age equal or greater than 60 years were also more likely to be anti-HBc positive which could only reflect that older people have a longer history of exposure to hepatitis B infection. The prevalence of hepatitis C is higher than the worldwide estimate.

CONCLUSION:

Buriticupu may be considered endemic for hepatitis B and C. Hepatitis B infection could be related to precarious living conditions and old age. Hepatitis C was not associated with the variables investigated in the present investigation.
RESUMO

CONTEXTO:

Infecção por hepatites B e C tem sido causa importante de morbimortalidade em todo o mundo. Entretanto, há poucas investigações sobre a prevalência e possíveis fatores de risco relacionados a tais doenças no Brasil, especialmente na região amazônica, onde há algumas regiões endêmicas para tais quadros clínicos.

OBJETIVOS:

Detectar a prevalência de hepatites B e C na cidade de Buriticupu, MA, localizada na região leste da Amazônia brasileira, e tentar investigar seus fatores de risco nessa área.

MÉTODOS:

Duzentos e quarenta e três indivíduos (46,5 por cento masculinos e 53,5 por cento femininos) foram investigados.

RESULTADOS:

A prevalência de hepatite C foi de 5,71 por cento (anti-HCV) e a de hepatite B foi de 40,74 por cento (anti-HBc). A prevalência de indivíduos com infecção atual ou com infecção crônica foi de 2,80 por cento (HBsAg). Houve relação estatisticamente significante entre anti-HBc e a distância da residência dos indivíduos do centro da cidade, o que pode refletir uma associação indireta entre tal quadro infeccioso e condições precárias de existência. Indivíduos com idade igual ou maior a 60 anos também apresentaram maior chance de apresentarem sorologia para anti-HBc, o que pode refletir apenas que pessoas mais velhas apresentam história maior de exposição à infecção. A prevalência de hepatite C é maior do que a mundial estimada.

CONCLUSÃO:

Buriticupu pode ser considerada endêmica para hepatites B e C. Hepatite B pode estar relacionada com precárias condições de vida e idade avançada. Hepatite C não foi associada com as variáveis investigadas na presente investigação.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Hepatitis C / Endemic Diseases / Hepatitis B Type of study: Diagnostic study / Etiology study / Prevalence study / Risk factors Limits: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: South America / Brazil Language: English Journal: Arq. gastroenterol Journal subject: Gastroenterology Year: 2010 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Maranhão Medical School/BR / University of São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Hepatitis C / Endemic Diseases / Hepatitis B Type of study: Diagnostic study / Etiology study / Prevalence study / Risk factors Limits: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: South America / Brazil Language: English Journal: Arq. gastroenterol Journal subject: Gastroenterology Year: 2010 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Maranhão Medical School/BR / University of São Paulo/BR