Breast cancer and oxidative stress in chemotherapy
Appl. cancer res
;
29(4): 150-156, Oct.-Dec. 2009.
Article
in English
| LILACS, Inca
| ID: lil-547646
ABSTRACT
Objective:
This revision characterizes the biomarkers used for analysis of the development of oxidative stress produced during breast cancer chemotherapy. Materials andmethods:
A search of articles indexed in digital databases (Lilacs, Bireme, PubMed, Scielo and digital libraries), along with publications printed as books, periodicals and articles not available online, in the period from 1979 to 2009.Conclusion:
Reactive oxygen and nitrogen species are produced, principally, during aerobic metabolism; however, its synthesis can be exacerbated or antioxidant defense reduced or more usually, both conditions can occurr in many pathophysiologic situations, leading to a net reactive species yelded. This unbalance is defined as oxidative stress. Stress biomarkers can be defined as predictive indicators able to detect in vivo oxidative damage and can be subdivided into antioxidant and pro-oxidants. To verify the antioxidant system, it is possible to analyze the superoxide dismutase enzymes, catalase and glutathione, along with vitamins A, E, C and glutathione among others. The analysis of pro-oxidants can be made through the verification of protein nitration and oxidation, heat shock proteins, lipoperoxidation, formation of aldehydes for malondialdehyde tests, 4-hydroxynonenal, oxidized LDL and isoprostanes or for chemiluminescent techniques. Advances in cancer detection through the identification of potential biomarkers consist of a promising strategy for the prevention and early identification of this pathology.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Breast Neoplasms
/
Oxidative Stress
/
Biomarkers, Pharmacological
/
Free Radicals
/
Neoplasms
/
Antioxidants
Limits:
Humans
Language:
English
Journal:
Appl. cancer res
Journal subject:
Neoplasms
Year:
2009
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Estadual de Londrina/BR
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