Effect of temozolomide treatment on the adenine nucleotide hydrolysis in blood serum of rats with implanted gliomas
Appl. cancer res
;
29(3): 118-124, July-Sept. 2009. tab, graf
Article
in English
| LILACS, Inca
| ID: lil-547659
ABSTRACT
Objective:
Adenine nucleotides and adenosine have many important functions in the physiological and pathological conditions. The measurement of these nucleotides in serum may be an auxiliary tool in the identification of cellular damage in many pathological conditions. The aim of this study is to examine the effect of chemotherapy treatment on nucleotide hydrolysis in the serum of rats following glioma implantation.Methods:
C6 glioma cells were injected in the right striatum of 60 day-old Wistar rats, and 20 days after the induction of gliomas, blood serum samples were prepared for measurement of ATP and AMP hydrolysis.Results:
The pathological analysis showed that the malignant gliomas induced by C6 injection and treated with temozolomide exhibited a reduction in malignant characteristics. The results demonstrated that the rats that underwent temozolomide treatment had a significant decrease (p<0.05) in blood serum hydrolysis of ATP and AMP when compared with the glioma group. None of the animals included in this study presented significant alterations in the activities of the serum enzymes alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase.Conclusion:
The decrease in the enzymatic hydrolysis of the ATP and AMP is probably related to the diminished malignant characteristics caused by temozolomide treatment on the gliomas in vivo.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Brain Neoplasms
/
Adenine
/
Glioma
/
Hydrolysis
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Appl. cancer res
Journal subject:
Neoplasms
Year:
2009
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of Rio Grande do Sul/BR
/
Pontifícia Universidade Católica of Rio Grande do Sul/BR
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