Tuberculin skin testing in HIV-infected patients in Campo Grande, Mato Grosso do Sul State, Brazil
J. venom. anim. toxins incl. trop. dis
;
16(2): 285-297, 2010. tab
Article
in English
| LILACS
| ID: lil-548850
ABSTRACT
A cross-sectional study on HIV/AIDS was carried out in 108 outpatients from the university hospital of the Federal University of Mato Grosso do Sul, Campo Grande, Brazil, from July to December 2008, to investigate latent tuberculosis infection using the tuberculin skin test (TST). The prevalence of positive results was 13.9 percent. The CD4+ T cell count (p = 0.091) and the diagnosis time (p = 0.010) were statistically significant when compared with TST positivity. In the cohort of HIV/AIDS patients who had latent tuberculosis infection, the median diagnosis time was eight years. Undetectable viral load presented significant association (p = 0.046) with tuberculosis infection. The fact that numerous individuals with HIV/AIDS infection presented a negative reaction to the tuberculin skin test is probably related to alterations in the cellular immune response induced by HIV infection. The tuberculin test is a useful tool for the detection of latent tuberculosis infection and should be performed in all HIV/AIDS individuals at the time of the diagnosis and on a yearly basis, if negative. Both the early identification of the tuberculosis infection by the tuberculin skin test at the moment of immunological restoration and chemoprophylaxis in infected individuals are mechanisms to control HIV/AIDS and tuberculosis coinfection.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Tuberculin Test
/
HIV
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
J. venom. anim. toxins incl. trop. dis
Journal subject:
Toxicology
Year:
2010
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Anhanguera Education Center/BR
/
Embrapa Beef Cattle/BR
/
Federal University of Mato Grosso do Sul/BR
/
Oswaldo Cruz Foundation/BR
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