High prevalence of the GSTM3*A/B polymorphism in sub-Sarahan African populations
Braz. j. med. biol. res
;
43(7): 677-680, July 2010. graf, tab
Article
in English
| LILACS
| ID: lil-550738
ABSTRACT
A 3-bp insertion/deletion polymorphism in intron 6 of GSTM3 (rs1799735, GSTM3*A/*B) affects the activity of the phase 2 xenobiotic metabolizing enzyme GSTM3 and has been associated with increased cancer risk. The GSTM3*B allele is rare or absent in Southeast Asians, occurs in 5-20 percent of Europeans but was detected in 80 percent of Bantu from South Africa. The wide genetic diversity among Africans led us to investigate whether the high frequency of GSTM3*B prevailed in other sub-Saharan African populations. In 168 healthy individuals from Angola, Mozambique and the São Tomé e Príncipe islands, the GSTM3*B allele was three times more frequent (0.74-0.78) than the GSTM3*A allele (0.22-0.26), with no significant differences in allele frequency across the three groups. We combined these data with previously published results to carry out a multidimensional scaling analysis, which provided a visualization of the worldwide population affinities based on the GSTM3 *A/*B polymorphism.
Full text:
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Index:
LILACS (Americas)
Main subject:
Polymorphism, Genetic
/
Gene Frequency
/
Glutathione Transferase
Type of study:
Prevalence study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Africa
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2010
Type:
Article
Affiliation country:
Brazil
/
Portugal
Institution/Affiliation country:
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP)/PT
/
Instituto Nacional de Câncer/BR
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