Interacciones de medicamentos y eventos adversos en fármacos utilizados en una unidad de cuidados intensivos / Drug interactions and adverse events induced by drugs used in an intensive care unit
Rev. méd. Chile
;
138(4): 452-460, abr. 2010. tab
Article
in Spanish
| LILACS
| ID: lil-553216
ABSTRACT
Background:
Eleven percent of hospitalized patients experience drug-drug interactions (DDIs), elevating morbidity, mortality and health care costs. Polypharmacy is very common in intensive care units (ICUs), increasing the risks of drug adverse events (AEs).Aim:
To assess DDIs in ICU patients. Material andMethods:
A prospective study conducted in the ICU of a private hospital, evaluating the frequency of DDIs, AEs developed and their relationship. Patients admitted to the ICU were included if they stayed at least three days in the ICU and received at least one studied drugResults:
Thirty fve patients aged 59 ± 16 years (24 women) were enrolled in the study. Seventy six DDIs and 60 AEs were recorded. Statistically signifcant associations were only found for midazolam-fentanyl-propofol with bradycardia and hypotension and amphotericin B-vancomycin and vancomycin-amikacin with acute renal failure (ARF). Relative risks were 10.4 (95 percent confdence intervals (CI) 1.59 - 68) for bradicardia, 5 (95 percent CI 1.082 - 23.4) for hypotension and 6.4 (95 percent CI 1.9 - 21.6) for ARF. The odds ratios were 125.2 (95 percent CI 3 - 250), 12.6 (95 percent CI 1.3 - 77) and 10.8 (95 percent CI 1.3 - 282) respectively.Conclusions:
DDIs associated with risk of AEs were fentanyl, propofol and midazolam for bradycardia and hypotension and amphotericin B-vancomycin and vancomycin-amikacin for ARF.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pharmaceutical Preparations
/
Drug Interactions
/
Drug-Related Side Effects and Adverse Reactions
/
Intensive Care Units
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Chile
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2010
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Clínica Dávila S.A/CL
/
Pontificia Universidad Católica de Chile/CL
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