Atrofia vellositaria duodenal inducida por micofenolato mofetil: caso clínico / Duodenal villous atrophy associated with Mycophenolate mofetil: report of one case
Rev. méd. Chile
;
138(5): 590-594, mayo 2010. ilus
Article
in Spanish
| LILACS
| ID: lil-553259
ABSTRACT
Mycophenolate mofetil (MMF) is an immunosupressor agent frequently used in patients after bone marrow or solid organ transplants. The most common adverse reactions of the drug are gastrointestinal, specially diarrhea and vomiting. We report a 53-year-old male, that received a heart transplant receiving immunosuppression with cyclosporine, mycophenolate mofetil and prednisone. Six months after the transplant, the patient started with diarrhea, anorexia and weight loss. A duodenal biopsy showed villous atrophy. Celiac disease and the presence of parasites were discarded. Mycophenolate mofetil was discontinued and one week later, diarrhea subsided. Two months later the patient was asymptomatic and recovered weight. A new duodenal biopsy showed absence of villous atrophy.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Duodenum
/
Immunosuppressive Agents
/
Microvilli
/
Mycophenolic Acid
Type of study:
Risk factors
Limits:
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2010
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de la Frontera/CL
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