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Estudo de fatores de risco, prevenção e controle da mucosite oral radioinduzida / Study of risk factors, prevention and control of the severe radiation-induced oral mucositis
São Paulo; s.n; 2001. 92 p. ilus, tab.
Thesis in Portuguese | LILACS, Inca | ID: lil-553387
RESUMO
Objetivo. Analisar fatores de risco e medidas de prevenção e controle da mucosite oral radioinduzida severa. Métodos. Este estudo incluiu duas partes (1) análise retrospectiva (n=100) e (2) análise prospectiva (n=96). Foram elegíveis pacientes com carcinomas de cabeça e pescoço submetidos a radioterapia tendo a boca incluída nos portais de radiação. Radioterapia ou quimioterapia prévias, quimioterapia concomitante, e interrupções do tratamento não relacionadas à toxicidade foram critérios de exclusão. Para classificação do performance funcional utilizou-se o índice ECOG PS. A mucosite foi avaliada segundo o critério de toxicidade aguda da WHO. Suporte clínico e odontológico foi realizado antes e durante a radioterapia, porém, apenas na Parte 2, suporte nutricional e um protocolo padronizado para abordagem das complicações orais agudas foram adicionados. Resultados. A freqüência da mucosite foi de 96% na coorte retrospectiva e 100% na prospectiva. Mucosite severa (WHO 3-4) resultou em 25% de interrupção do tratamento na Parte 1, e somente 1% na Parte 2 (p<0,0001). Pobre performance funcional - ECOG PS 3 (OR= 5,0) e sexo feminino (OR=6,6) foram identificados como fatores de risco independentes para mucosite severa na Parte 1; e, história de tabagismo e etilismo associados (OR=5,5), irritação ocasional da mucosa (OR=4,9) e candidíase (OR=7,6) na Parte 2. Conclusões. Controle rigoroso da mucosite pode controlar casos severos e reduzir a interrupção da radioterapia. Fatores de risco devem ser considerados na elaboração de protocolos específicos para prevenção e controle da mucosite oral...
ABSTRACT
Objective. To analyze risk factors and approach to preventing and controlling severe radiation induced oral mucositis. Methods. This study comprises two parts ( 1) a retrospective analysis and (2) a prospective cohort of patients with head and neck carcinomas, submitted to radiotherapy (oral cavity included in radiation field) included in this survey. Prior radio or chemotherapy, radiochemotherapy, treatment breaks not related to treatment-related toxicity were exclusion criteria. Functional status was scored by ECOG PS. Mucositis severity was evaluated by the WHO index. Clinicai and dental support was given before and during treatment, however, nutritional support was given only to patients in the prospective group, as a standardized protocol of measures for approaching acute oral radiotherapyrelated complications. Results. Some degree of mucositis occurred in most patients (96% of Part 1 and 1 00°/o of Part 2). Severe mucositis was developed by approximately 29°/o, however treatment interruption occurred in 25°/o of Part 1 versus 1% of Part 2 patients (p<0,0001 ). Poor functional status (OR= 5,0) and female gender (OR=6,6) were identified as independents risk factors to severe oral mucositis (Part 1 ), besides combined use of tobacco and alcohol (OR=5,5), occasional mucosa irritation (OR=4,9) and candidiasis (OR=7,6) in prospective cohort. Conclusions. An aggressive approach of oral mucositis may contrai severe cases and decrease unplanned gaps in radiotherapy. Risk factors must be considered when making protocols for preventing and controlling oral mucositis
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Radiotherapy / Stomatitis / Risk Factors / Mucositis / Head and Neck Neoplasms Type of study: Diagnostic study / Etiology study / Practice guideline / Prognostic study / Risk factors Limits: Adult / Humans / Male Language: Portuguese Year: 2001 Type: Thesis

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Full text: Available Index: LILACS (Americas) Main subject: Radiotherapy / Stomatitis / Risk Factors / Mucositis / Head and Neck Neoplasms Type of study: Diagnostic study / Etiology study / Practice guideline / Prognostic study / Risk factors Limits: Adult / Humans / Male Language: Portuguese Year: 2001 Type: Thesis