Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study
Braz. oral res
;
24(2): 170-176, Apr.-June 2010. ilus
Article
in English
| LILACS
| ID: lil-553903
ABSTRACT
Clinical and experimental studies have demonstrated some negative effect of hypertension on bone mineral density. The aim of this study was to evaluate bone healing and trabecular bone area (TBA) in spontaneously hypertensive rats (SHR), a well-established model of essential hypertension, when compared to normotensive rats (NTR). A critical-size defect was surgically created in the right tibia of SHR (n = 12) and normotensive rats (NTR; n = 12), while the contralateral tibia was left intact. Eight days later, the animals were sacrificed and the specimens processed in order to obtain decalcified sections. The area of newly-formed bone (NB) within the defect of the right tibia and the TBA in the left tibia were histometrically evaluated. At 8 days post-operative, SHR presented a significantly smaller area of NB when compared to NTR (p < 0.05). In addition, SHR demonstrated a lower TBA than NTR group. In conclusion, the present study demonstrated that SHR rats presented a disturbed bone healing and reduced TBA.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Tibia
/
Bone Regeneration
/
Fracture Healing
/
Hypertension
Limits:
Animals
Language:
English
Journal:
Braz. oral res
Journal subject:
Dentistry
Year:
2010
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Guarulhos University/BR
/
Nove de Julho University/BR
Similar
MEDLINE
...
LILACS
LIS