Diagnóstico "in vitro" de la deficiencia de ACIL-CoA deshidrogenasa de cadena corta / \"In vitro\" diagnosis of short chain acyl-CoA dehydrogenase deficiency
Biosalud
;
8(1): 96-101, ene.-dic. 2009. tab
Article
in Spanish
| LILACS
| ID: lil-555165
RESUMEN
La acil-CoA deshidrogenasa de cadena corta (SCAD) cataliza la primera reacción de la degradación de ácidos grasos de 4 a 6 átomos de carbono. Su deficiencia debe ser siempre confirmada por estudios de laboratorio. En el presente trabajo, fueron incubados fibroblastos de pacientes que presentaban la deficiencia de SCAD, en presencia de sustratos tritiados. Fue encontrada diferencia significativa (p<0,05) al comparar la degradación de palmitato y miristato tritiado entre controles y pacientes con deficiencia de SCAD.
ABSTRACT
Short-chain acyl-CoA dehydrogenase (SCAD) is the key enzyme for degrading fatty acids with a 4-6 atoms carbon chain. It is necessary to always confirm this deficiency using laboratory methods. Fibroblasts of patients suffering SCAD deficiency were incubated with tritiated palmitate and miristatesubstrates. A significant difference (p<0.05) was found when comparing tritiated palmitate and miristate degradation between controls and patients suffering SCAD deficiency.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Acyl Coenzyme A
/
Acyl-CoA Dehydrogenase
/
DNA-Binding Proteins
Type of study:
Diagnostic study
Language:
Spanish
Journal:
Biosalud
Journal subject:
Medicine
Year:
2009
Type:
Article
Affiliation country:
Colombia
/
Spain
Institution/Affiliation country:
Corporació Sanitaria Clínic/ES
/
Universidad de Caldas/CO
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