Recovery of hormone sensitivity after salvage brachytherapy for hormone refractory localized prostate cancer
Int. braz. j. urol
;
36(3): 283-291, May-June 2010. graf
Article
in English
| LILACS
| ID: lil-555187
ABSTRACT
PURPOSE:
Recent work has demonstrated the return of hormone sensitivity after palliative chemotherapy in androgen independent prostate cancer. We wished to establish whether a similar phenomenon existed in patients with no exposure to chemotherapy. MATERIALS ANDMETHODS:
A review of hormone resistant patients who had received salvage brachytherapy for localized prostate cancer after previous external beam radiotherapy was undertaken. Three patients with subsequent biochemical relapse responded to the rechallenge with hormonal treatment.RESULTS:
The series of patients presented here demonstrates this phenomenon occurs after salvage brachytherapy with no exposure to chemotherapy. Recovery of sensitivity is demonstrated both to androgen deprivation and to androgen receptor antagonism. The recovery of hormone sensitivity was surprisingly durable, ranging from eight months to over twenty-one months.CONCLUSIONS:
Hormone sensitivity may be recovered after salvage brachytherapy. Potential mechanisms underlying these observations are discussed and the likely central role of the activity of the androgen receptor highlighted. The relevance of these findings to the management of advanced prostate cancer is considered including thoughts on the practice of intermittent anti-androgen therapy.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Prostatic Neoplasms
/
Brachytherapy
/
Neoplasm Recurrence, Local
Type of study:
Diagnostic study
Limits:
Aged
/
Humans
/
Male
Language:
English
Journal:
Int. braz. j. urol
Journal subject:
Urology
Year:
2010
Type:
Article
Affiliation country:
United kingdom
Institution/Affiliation country:
St Bartholomew's Hospital/GB
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