Anti-hypertensive drugs have different effects on ventricular hypertrophy regression: [review]
Clinics
;
65(7): 723-728, 2010. tab
Article
in English
| LILACS
| ID: lil-555505
ABSTRACT
OBJECTIVES:
There is a direct relationship between the regression of left ventricular hypertrophy (LVH) and a decreased risk of mortality. This investigation aimed to describe the effects of anti-hypertensive drugs on cardiac hypertrophy through a meta-analysis of the literature.METHODS:
The Medline (via PubMed), Lilacs and Scielo databases were searched using the subject keywords cardiac hypertrophy, antihypertensive and mortality. We aimed to analyze the effect of anti-hypertensive drugs on ventricle hypertrophy.RESULTS:
The main drugs we described were enalapril, verapamil, nifedipine, indapamina, losartan, angiotensin-converting enzyme inhibitors and atenolol. These drugs are usually used in follow up programs, however, the studies we investigated used different protocols. Enalapril (angiotensin-converting enzyme inhibitor) and verapamil (Ca++ channel blocker) caused hypertrophy to regress in LVH rats. The effects of enalapril and nifedipine (Ca++ channel blocker) were similar. Indapamina (diuretic) had a stronger effect than enalapril, and losartan (angiotensin II receptor type 1 (AT1) receptor antagonist) produced better results than atenolol (selective â1 receptor antagonist) with respect to LVH regression.CONCLUSION:
The anti-hypertensive drugs induced various degrees of hypertrophic regression.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Hypertrophy, Left Ventricular
/
Antihypertensive Agents
Type of study:
Etiology study
/
Risk factors
/
Systematic reviews
Limits:
Animals
/
Humans
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2010
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Faculdade de Medicina do ABC/BR
/
Universidade Estadual Paulista/BR
/
Universidade Federal de São Paulo/BR
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