Fructose and cardiometabolic disorders: the controversy will, and must, continue: [review]
Clinics
;
65(7): 729-738, 2010. ilus
Article
in English
| LILACS
| ID: lil-555506
ABSTRACT
The present review updates the current knowledge on the question of whether high fructose consumption is harmful or not and details new findings which further pushes this old debate. Due to large differences in its metabolic handling when compared to glucose, fructose was indeed suggested to be beneficial for the diet of diabetic patients. However its growing industrial use as a sweetener, especially in soft drinks, has focused attention on its potential harmfulness, possibly leading to dyslipidemia, obesity, insulin resistance/metabolic syndrome and even diabetes. Many new data have been generated over the last years, confirming the lipogenic effect of fructose as well as risks of vascular dysfunction and hypertension. Fructose exerts various direct effects in the liver, affecting both hepatocytes and Kupffer cells and resulting in non-alcoholic steatotic hepatitis, a well known precursor of the metabolic syndrome. Hepatic metabolic abnormalities underlie indirect peripheral metabolic and vascular disturbances, for which uric acid is possibly the culprit. Nevertheless major caveats exist (species, gender, source of fructose, study protocols) which are detailed in this review and presently prevent any firm conclusion. New studies taking into account these confounding factors should be undertaken in order to ascertain whether or not high fructose diet is harmful.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Sweetening Agents
/
Vascular Diseases
/
Metabolic Syndrome
/
Diet
/
Fructose
Type of study:
Etiology study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2010
Type:
Article
Affiliation country:
France
Institution/Affiliation country:
INSA Lyon/FR
/
University of Burgundy/FR
Similar
MEDLINE
...
LILACS
LIS