Enhanced susceptibility of Candida albicans to chlorhexidine under anoxia
Braz. j. oral sci
;
8(2): 105-110, Apr.-June 2009. graf
Article
in English
| LILACS, BBO
| ID: lil-556475
ABSTRACT
Aim:
Periodontal pockets can be colonized not only by bacteria, but also by Candida albicans. However, its role in periodontitis is unknown. This study evaluated the inhibitory performance of chlorhexidine digluconate under normoxic and anoxic conditions against 16 strains of C. albicans from periodontal pockets and other 20 from the oral mucosa.Methods:
Strains were grown in normoxia and anoxia to adapt themselves to the different atmospheric conditions. Microdilution-based assays were carried out to determine the minimum concentrations of chlorhexidine that may restrain the conditioned candidal strains, in normoxia (normoxic MIC) and anoxia (anoxic MIC). The Mann-Whitney U test was used to evaluate the antimicrobial effect of chlorhexidine on C. albicans under normoxic and anoxic conditions (α = 0.05).Results:
The normoxic MIC of chlorhexidine varied broadly from 150 to 1200 µg/mL, whereas its anoxic MIC varied narrower from 2.34 to 37.5 µg/mL. Regarding the origins of strains, no statistically significant differences (p > 0.05) were found.Conclusions:
These results indicate that anoxic environmental conditions, compatible with periodontal pockets, tend to enhance C. albicans susceptibility to chlorhexidine.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Periodontal Pocket
/
Candida albicans
/
Chlorhexidine
Limits:
Humans
Language:
English
Journal:
Braz. j. oral sci
Journal subject:
Dentistry
Year:
2009
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Pontifícia Universidade Católica do Paraná (PUCPR)/BR
/
Universidade Estadual de Campinas (Unicamp)/BR
/
University of Hong Kong/CN
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