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Efficacy of low-level laser therapy and aluminum hydroxide in patients with chemotherapy and radiotherapy-induced oral mucositis
Lima, Aline Gouvêa de; Antequera, Reynaldo; Peres, Maria Paula Siqueira de Melo; Snitcosky, Igor Moysés Longo; Federico, Miriam Hatsue Honda; Villar, Rosângela Correa.
  • Lima, Aline Gouvêa de; University of São Paulo. Medical School. Clinics Hospital. São Paulo. BR
  • Antequera, Reynaldo; University of São Paulo. Medical School. Clinics Hospital. São Paulo. BR
  • Peres, Maria Paula Siqueira de Melo; University of São Paulo. Medical School. Clinics Hospital. São Paulo. BR
  • Snitcosky, Igor Moysés Longo; University of São Paulo. Medical School. São Paulo. BR
  • Federico, Miriam Hatsue Honda; University of São Paulo. Medical School. São Paulo. BR
  • Villar, Rosângela Correa; University of São Paulo. Medical School. Clinics Hospital. São Paulo. BR
Braz. dent. j ; 21(3): 186-192, 2010. graf, tab
Article in English | LILACS | ID: lil-556815
ABSTRACT
This study evaluated the efficacy of low-level laser therapy (LLLT) and aluminum hydroxide (AH) in the prevention of oral mucositis (OM). A prospective, comparative and non-randomized study was conducted with 25 patients with head and neck cancer subjected to radiotherapy (RT) or radiochemotherapy (RCT). Twelve patients received LLLT (830 nm, 15 mW, 12 J/cm²) daily from the 1st day until the end of RT before each sessions during 5 consecutive days, and the other 13 patients received AH 310 mg/5 mL, 4 times/day, also throughout the duration of RT, including weekends. OM was measured using an oral toxicity scale (OTS) and pain was measured using the visual analogue scale (VAS). EORTC questionnaires were administered to the evaluate impact of OM on quality of life. The LLLT group showed lower mean OTS and VAS scores during the course of RT. A significant difference was observed in pain evaluation in the 13th RT session (p=0.036). In both groups, no interruption of RT was needed. The prophylactic use of both treatments proposed in this study seems to reduce the incidence of severe OM lesions. However, the LLLT was more effective in delaying the appearance of severe OM.
RESUMO
Este estudo avaliou a eficácia da terapia do laser de baixa potência (LBP) e hidróxido de alumínio (HA) na prevenção da mucosite oral (MO). Um estudo prospectivo, comparativo e não-aleatorizado foi conduzido com 25 pacientes com câncer de cabeça e pescoço submetidos a radioterapia (RT) ou radioquimioterapia (RT/QT). Doze pacientes receberam LBP (830 nm, 15 mW, 12 J/cm²) diariamente desde o primeiro dia até o final da RT antes de cada sessão durante 5 dias consecutivos, e os outros 13 pacientes receberam HA 310 mg/5 mL, 4 vezes ao dia, também por toda a duração da RT, incluindo finais de semana. MO foi mensurada usando uma escala de toxicidade oral (ETO) e dor foi mensurada usando a escala visual analógica (EVA). Questionários da EORTC foram administrados para a avaliação do impacto da MO na qualidade de vida. O grupo LBP mostrou menores médias dos escores da ETO e EVA durante o curso da RT. Uma diferença significante foi observada na avaliação da dor na 13ª sessão de RT (p=0,036). Em ambos os grupos, nenhuma interrupção da RT foi necessária. O uso profilático de ambos os tratamentos propostos neste estudo parece reduzir a incidência de lesões severas de MO. No entanto, o LBP foi mais efetivo no atraso do aparecimento da MO severa.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Stomatitis / Low-Level Light Therapy / Aluminum Hydroxide / Head and Neck Neoplasms / Mouthwashes Type of study: Controlled clinical trial / Etiology study / Observational study / Risk factors Limits: Humans Language: English Journal: Braz. dent. j Journal subject: Dentistry Year: 2010 Type: Article Affiliation country: Brazil Institution/Affiliation country: University of São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Stomatitis / Low-Level Light Therapy / Aluminum Hydroxide / Head and Neck Neoplasms / Mouthwashes Type of study: Controlled clinical trial / Etiology study / Observational study / Risk factors Limits: Humans Language: English Journal: Braz. dent. j Journal subject: Dentistry Year: 2010 Type: Article Affiliation country: Brazil Institution/Affiliation country: University of São Paulo/BR