Microbiological epidemiological history of meningococcal disease in Rio de Janeiro, Brazil
Braz. j. infect. dis
;
14(3): 242-251, May-June 2010. ilus, tab
Article
in English
| LILACS
| ID: lil-556836
ABSTRACT
The main objectives of the present study were to investigate the clinical and laboratory features of meningococcal disease in the city of Rio de Janeiro, Brazil, during the overlap of 2 epidemics in the 1990s. We conducted a study of a series of cases of meningococcal disease admitted in a Meningitis Reference Hospital. All clinical isolates available were analyzed by means of microbiological epidemiological markers. In 1990, Neisseria meningitidis serogroup B4,7P1.19,15, 1.7,1 sulfadiazine-resistant of the ET-5 complex emerged causing epidemic disease. Despite mass vaccination campaign (VaMengoc B+C®), the ET-5 clone remained hyperendemic after the epidemic peaked. In 1993 to 1995, an epidemic of serogroup C belonged to the cluster A4 overlapped, with a significant shift in the age distribution toward older age groups and an increase of sepsis. Serogroup C epidemics are a recurrent problem in Rio de Janeiro, which can be hindered with the introduction of a conjugate vaccine. We hope the data presented here brings useful information to discuss vaccines strategies and early management of suspected cases.
Full text:
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Index:
LILACS (Americas)
Main subject:
Sepsis
/
Epidemics
/
Meningitis, Meningococcal
/
Neisseria meningitidis
Type of study:
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Infant, Newborn
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2010
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Instituto Adolfo Lutz/BR
/
Instituto Estadual de Infectologia São Sebastião/BR
/
Instituto Oswaldo Cruz/BR
/
Universidade Federal do Rio de Janeiro/BR
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