The effect of chronic administration of L-arginine on the learning and memory of estradiol-treated ovariectomized rats tested in the morris water maze
Clinics
;
65(8): 803-807, June 2010. graf
Article
in English
| LILACS
| ID: lil-557008
ABSTRACT
OBJECTIVE:
The present study was carried out to evaluate the effect of L-arginine on the learning and memory of estradiol-treated ovariectomized (OVX) rats.METHODS:
Forty-eight rats were divided into six groups (1) sham, (2) OVX, (3) sham-Est, (4) OVX-Est, (5) sham-Est-LA, and (6) OVX-Est-LA. The animals of the sham-Est and OVX-Est groups were treated by weekly injection of estradiol valerate (2mg/kg). The sham-Est-LA and OVX-Est-LA groups were treated in the same manner but with an additional daily injection of L-arginine (200mg/kg). After eight weeks, animals of all groups were tested in the Morris water maze. The escape latency and path traveled to reach the platform were compared between groups.RESULTS:
Time latency and path length in the OVX group were significantly higher than in the sham group (P<0.05). The OVX-Est group had a significantly shorter traveled path length and time latency compared to the OVX group (P<0.001). Time latency and path length in the sham-Est group was significantly higher than in the sham group (P<0.001). Time latency and path length in the OVX-Est-LA group were significantly higher than in the OVX-Est group.CONCLUSIONS:
These results allow us to propose that chronic treatment with estradiol enhances the spatial learning and memory of OVX rats, and that long term L-arginine treatment attenuates the effects of improvement produced by estradiol in OVX rats.
Full text:
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Index:
LILACS (Americas)
Main subject:
Arginine
/
Behavior, Animal
/
Maze Learning
/
Estradiol
/
Estrogens
/
Memory
Limits:
Animals
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2010
Type:
Article
Affiliation country:
Iran
Institution/Affiliation country:
Isfahan University of Medical Sciences/IR
/
Mashhad University of Medical Sciences/IR
/
University of Tehran/IR
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