Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats
J. appl. oral sci
;
18(3): 273-278, May-June 2010. ilus
Article
in English
| LILACS
| ID: lil-557093
ABSTRACT
Castor oil bean cement (COB) is a new material that has been used as an endodontic sealer, and is a candidate material for direct pulp capping. OBJECTIVE:
The purpose of this study was to evaluate the biocompatibility of a new formulation of COB compared to calcium hydroxide cement (CH) and a control group without any material, in the subcutaneous tissue of rats. MATERIAL ANDMETHODS:
The materials were prepared, packed into polyethylene tubes, and implanted in the rat dorsal subcutaneous tissue. Animals were sacrificed at the 7th and 50th days after implantation. A quantitative analysis of inflammatory cells was performed and data were subjected to ANOVA and Tukey's tests at 5 percent significance level.RESULTS:
Comparing the mean number of inflammatory cells between the two experimental groups (COB and CH) and the control group, statistically significant difference (p=0.0001) was observed at 7 and 50 days. There were no significant differences (p=0.111) between tissue reaction to CH (382 inflammatory cells) and COB (330 inflammatory cells) after 7 days. After 50 days, significantly more inflammatory cells (p=0.02) were observed in the CH group (404 inflammatory cells) than in the COB group (177 inflammatory cells).CONCLUSIONS:
These results demonstrate that the COB cement induces less inflammatory response within long periods.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Biocompatible Materials
/
Calcium Hydroxide
/
Castor Oil
/
Subcutaneous Tissue
/
Pulp Capping and Pulpectomy Agents
Limits:
Animals
Language:
English
Journal:
J. appl. oral sci
Journal subject:
Dentistry
Year:
2010
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Superior School of Cruzeiro/BR
/
São Paulo State University/BR
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