High prevalence of drug-resistant tuberculosis and other mycobacteria among HIV-infected patients in Brazil: a systematic review
Mem. Inst. Oswaldo Cruz
;
105(6): 838-841, Sept. 2010. tab
Article
in English
| LILACS, SES-SP
| ID: lil-560673
ABSTRACT
There is a little-noticed trend involving human immunodeficiency virus (HIV)-infected patients suspected of having tuberculosis the triple-treatment regimen recommended in Brazil for years has been potentially ineffective in over 30 percent of the cases. This proportion may be attributable to drug resistance (to at least 1 drug) and/or to infection with non-tuberculous mycobacteria. This evidence was not disclosed in official statistics, but arose from a systematic review of a few regional studies in which the diagnosis was reliably confirmed by mycobacterial culture. This paper clarifies that there has long been ample evidence for the potential benefits of a four-drug regimen for co-infected patients in Brazil and it reinforces the need for determining the species and drug susceptibility in all positive cultures from HIV-positive patients.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
AIDS-Related Opportunistic Infections
/
Tuberculosis, Multidrug-Resistant
/
Mycobacterium Infections, Nontuberculous
/
Antitubercular Agents
Type of study:
Prevalence study
/
Risk factors
/
Systematic reviews
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS