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Microsurgical clipping in forty patients with unruptured anterior cerebral circulation aneurysms: an investigation into cognitive outcome / Clipagem microcirúrgica em 40 pacientes com aneurisma de circulação cerebral anterior não-roto: uma investigação cognitiva
Pereira-Filho, Arthur A; Pereira, Adriana G; Faria, Mário B; Lima, Leonardo C. S; Portuguez, Mirna W; Kraemer, Jorge L.
  • Pereira-Filho, Arthur A; s.af
  • Pereira, Adriana G; s.af
  • Faria, Mário B; s.af
  • Lima, Leonardo C. S; s.af
  • Portuguez, Mirna W; s.af
  • Kraemer, Jorge L; s.af
Arq. neuropsiquiatr ; 68(5): 770-774, Oct. 2010. ilus, tab
Article in English | LILACS | ID: lil-562806
ABSTRACT

OBJECTIVE:

It is a consensus that most unruptured intracranial aneurysms (UIA) can be treated with acceptably low morbidity. However, some studies recently reported postoperative cognitive impairment, suggesting that it could be attributable to surgical damage. Our goal is to evaluate cognitive function before and after microsurgical clipping in patients with UIA.

METHOD:

A consecutive series of 40 patients who underwent microsurgical clipping for UIA were studied. The cognitive assessment (Mini Mental State Examination, MMSE) was performed immediately before and at least one month after surgery. Paired Student's "t" test and analysis of variance (ANOVA) were used for statistical purposes.

RESULTS:

The mean MMSE score in the preoperative analysis was 28.12 (SD, 1.34). In the postoperative period the mean MMSE score was 28.40 (SD, 1.46). Paired Student's "t" test was applied to the scores and no significant difference was found (p=0.315). ANOVA did not find independent associations between MMSE scores and age, hypertension, smoking, dyslipidemia, education, aneurysm location, number, laterality or size.

CONCLUSION:

The present study suggests that microsurgical clipping for UIA does not result in major cognitive dysfunction as determined by the MMSE.
RESUMO

OBJETIVO:

É consenso que a maioria dos aneurismas intracranianos não-rotos (AINR) podem ser tratados com aceitável taxa de morbidade. Entretanto, alguns estudos reportaram déficits cognitivos no pós-operatório, sugerindo que poderiam ser atribuídos ao dano cirúrgico. O objetivo desse estudo é avaliar a função cognitiva antes e após clipagem microcirúrgica em pacientes com AINR.

MÉTODO:

Uma série de 40 pacientes com AINR submetidos à clipagem microcirúrgica foi estudada. A avaliação cognitiva (Mini Exame do Estado Mental, MEEM) foi realizada antes e após a intervenção cirúrgica. A análise estatística foi realizada com teste "t" de Student e análise de variância (ANOVA).

RESULTADOS:

A média dos escores do MEEM na análise pré-operatória foi 28,12 (DP, 1,34). No período pós-operatório, a média dos escores foi 28,40 (DP, 1,46). Não houve diferença estatística (teste "t" de Student; p=0,315). A ANOVA não encontrou associações independentes entre os escores de MEEM e idade, hipertensão, tabagismo, dislipidemia, educação e características dos aneurismas (topografia, número, lado e tamanho).

CONCLUSÃO:

O presente estudo sugere que a clipagem microcirúrgica não está associada a danos cognitivos maiores em pacientes com AINR.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Postoperative Complications / Surgical Instruments / Intracranial Aneurysm / Cognition Disorders / Microsurgery Type of study: Diagnostic study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2010 Type: Article

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Full text: Available Index: LILACS (Americas) Main subject: Postoperative Complications / Surgical Instruments / Intracranial Aneurysm / Cognition Disorders / Microsurgery Type of study: Diagnostic study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2010 Type: Article