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Markers of autoimmune liver diseases in postmenopausal women with osteoporosis
Demirdal, Umit Secil; Ciftci, Ihsan Hakkı; Kavuncu, Vural.
  • Demirdal, Umit Secil; s.af
  • Ciftci, Ihsan Hakkı; s.af
  • Kavuncu, Vural; s.af
Clinics ; 65(10): 971-974, 2010. tab
Article in English | LILACS | ID: lil-565979
ABSTRACT

INTRODUCTION:

Osteoporosis is a common complication of chronic liver diseases. However, there is limited information about autoimmune liver diseases as a factor of secondary osteoporosis. Therefore, we aimed to investigate the autoantibodies of autoimmune liver diseases in patients with osteoporosis.

METHODS:

One hundred fifty female patients with postmenopausal osteoporosis were included. Bone mineral density was measured by dual energy X-ray absorptiometry. We analysized autoantibodies including antinuclear antibodies, liver membrane antibodies, anti-liver/kidney microsomal autoantibodies1, liver-specific protein, antismooth muscle antibodies, and anti-mitochondrial antibodies by indirect immunofluorescence. Serum was assayed for the levels of aminotransferases.

RESULTS:

The mean age of the patients was 63,13±8,6 years. The mean values of L1-L4 T-scores and femur total T-scores were -3,08±0,58 and -1,53±0,81, respectively. Among the 150 patients with osteoporosis, 14 (9.3 percent) were antinuclear antibodies, four (2.7 percent) were liver membrane antibodies, three (2.0 percent) were anti-liver/kidney microsomal autoantibodies1, and two (1.3 percent) were liver-specific protein positive. None of the patients had anti-mitochondrial antibodies or smooth muscle antibodies positivity. The mean values of levels of aminotransferases were within normal range.

CONCLUSIONS:

The presence of liver membrane antibodies, liver-specific protein, and anti-liver/kidney microsomal autoantibodies1 has permitted us to see that there may be some suspicious clues of autoimmune liver diseases in patients with osteoporosis as a secondary risk factor. On the other hand, there is a need for comprehensive studies with a larger sample size and studies designed to compare the results with a normal population to understand the clinical importance of our findings.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Aspartate Aminotransferases / Autoantibodies / Autoimmune Diseases / Osteoporosis, Postmenopausal / Alanine Transaminase / Liver Diseases Type of study: Etiology study / Risk factors Limits: Female / Humans Language: English Journal: Clinics Journal subject: Medicine Year: 2010 Type: Article

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Full text: Available Index: LILACS (Americas) Main subject: Aspartate Aminotransferases / Autoantibodies / Autoimmune Diseases / Osteoporosis, Postmenopausal / Alanine Transaminase / Liver Diseases Type of study: Etiology study / Risk factors Limits: Female / Humans Language: English Journal: Clinics Journal subject: Medicine Year: 2010 Type: Article