Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice
Clinics
;
65(10): 1037-1042, 2010. ilus, tab
Article
in English
| LILACS
| ID: lil-565991
ABSTRACT
INTRODUCTION:
We investigated the antianxiety and sedative effects of the essential oil of Ducrosia anethifolia. Boiss. (Apiaceae).METHODS:
We used elevated plus maze, spontaneous motor activity and ketamine-induced sleep tests in mice. In addition, the essential oil was analyzed by GC/MS. Twenty compounds were identified, and n-decanal (70.1 percent) and alpha-pinene (12.4 percent) constituted the major components.RESULTS:
In elevated plus maze, Ducrosia anethifolia essential oil at doses of 25-200 mg/kg increased the percentage of open arm time and entries. Unlike diazepam, ducrosia anethifolia essential oil could not suppress spontaneous motor activity and did not alter ketamine-induced sleep parameters. These results are indicative of antianxiety effect of Ducrosia anethifolia essential oil without sedative effect.
Full text:
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Index:
LILACS (Americas)
Main subject:
Plants, Medicinal
/
Sleep
/
Anti-Anxiety Agents
/
Plant Oils
/
Maze Learning
/
Hypnotics and Sedatives
/
Motor Activity
Limits:
Animals
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2010
Type:
Article
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