The anticancer drug tamoxifen is active against Trypanosoma cruzi in vitro but ineffective in the treatment of the acute phase of Chagas disease in mice
Mem. Inst. Oswaldo Cruz
;
105(7): 945-948, Nov. 2010. graf, tab
Article
in English
| LILACS
| ID: lil-566191
ABSTRACT
The activity of the antineoplastic drug tamoxifen was evaluated against Trypanosoma cruzi. In vitro activity was determined against epimastigote, trypomastigote and amastigote forms of CL14, Y and Y benznidazole resistant T. cruzi strains. Regardless of the strain used, the drug was active against all life-cycle stages of the parasite with a half maximal effective concentration ranging from 0.7-17.9 µM. Two experimental models of acute Chagas disease were used to evaluate the in vivo efficacy of treatment with tamoxifen. No differences in parasitemia and mortality were observed between control mock-treated and tamoxifen-treated mice.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Tamoxifen
/
Trypanocidal Agents
/
Trypanosoma cruzi
/
Chagas Disease
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS