Registro de Alteplasa en Síndromes Coronarios Agudos con elevación del ST (REALSICA) / Alteplase in acute coronary syndromes
Arch. cardiol. Méx
;
78(3): 255-264, jul.-sept. 2008.
Article
in Spanish
| LILACS
| ID: lil-566664
ABSTRACT
OBJECTIVE:
The registry intends to establish the safety and security of one-hour 100 mg alteplase infusion and 50 mg in 30 minutes to facilitate percutaneous coronary intervention (PCI) in a cardiology hospital with primary angioplasty program (24 hours 365 days a year) with current doses of unfractionated heparin and enoxaparin. METHODS ANDRESULTS:
REALSICA II is a prospective registry that included 103 patients with final diagnosis of ST elevation myocardial infarction in which Alpert's quality criteria were used. Seventy two patients were under one-hour 100 mg alteplase infusion and thirty one under 30 minutes 50 mg alteplase infusion to facilitate PCI. Patients were young and predominantly males. In both groups > 50% had extensive ST elevation myocardial infarction and 68% were Killip & Kimball I. The majority received reperfusion > 3 hours after the onset of symptoms. In-hospital and follow-up treatment were compliant with Mexican Cardiology Society guidelines. ECG reperfusion was observed in 59% and TIMI III flow in 19% of PCI group. Any intracranial hemorrhage was observed. Global cardiovascular mortality was 11%. Patients under PCI had low incidence of recurrent ischemia and reinfarction.CONCLUSION:
REALSICA registry showed in non-complicate acute myocardial infarction ST elevation safety and security of one-hour 100 mg alteplase infusion with current recommended unfractionated heparin and enoxaparin doses in ST elevation myocardial infarction. In complicated patients the regimen to facilitate PCI was associated with increased hemorrhagic complications and requires further research.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Angioplasty, Balloon, Coronary
/
Registries
/
Tissue Plasminogen Activator
/
Acute Coronary Syndrome
/
Fibrinolytic Agents
Type of study:
Practice guideline
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Mexico
Language:
Spanish
Journal:
Arch. cardiol. Méx
Journal subject:
Cardiology
Year:
2008
Type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Instituto Mexicano del Seguro Social/MX
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