El tamaño y la composición de las lipoproteínas de alta densidad (HDL) se modifican en la rata por una dieta suplementada con aguacate Hass (Persea americana Miller) / High-density lipoproteins (HDL) size and composition are modified in the rat by a diet supplemented with Hass avocado (Persea americana Miller)
Arch. cardiol. Méx
;
77(1): 17-24, ene.-mar. 2007. tab, ilus
Article
in Spanish
| LILACS
| ID: lil-566911
ABSTRACT
PURPOSE: To determine the effects of dietary avocado on HDL structure and their associated enzyme, paraoxonase 1 (PON1). METHODS: Fifteen Wistar male rats received avocado as part of their daily meal (5 g by 17.5 g chow diet), keeping the caloric intake similar to the control group (n=15) that received their usual chow diet. After 5 weeks, HDL were isolated by sequential ultracentrifugation and their size and chemical composition were analyzed. PON1 was determined in serum spectrophotometrically using phenylacetate as substrate. RESULTS: Rats that received avocado had about 27% lower triglycerides plasma levels whereas their HDL-cholesterol was 17% higher as compared to control group. The mean HDL Stokes diameter was significantly lower in avocado group (11.71 +/- 0.8 vs. 12.27 +/- 0.26 nm, in control group, p < 0.05). The HDL size decrease was associated to a lower content of protein, particularly of apo Al, with a concomitant higher proportion of phospholipids in HDL isolated from avocado group. HDL structural modifications induced by avocado were not related to modifications of LCAT and PLTP activities, but occurred in parallel with higher serum levels of PON1 activity when compared to the controls (57.4 +/- 8.9 vs. 43.0 +/- 5.6 micromol/min/mL serum, p < 0.05). CONCLUSIONS: The inclusion of avocado in the diet decreased plasma triglycerides, increased HDL-cholesterol plasma levels and modified HDL structure. The latter effect may enhance the antiatherogenic properties of HDL since PON1 activity also increased as a consequence of avocado.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Triglycerides
/
Dietary Supplements
/
Persea
/
Aryldialkylphosphatase
/
Lipoproteins, HDL
/
Cholesterol, HDL
Limits:
Animals
Language:
Spanish
Journal:
Arch. cardiol. Méx
Journal subject:
Cardiology
Year:
2007
Type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Instituto Nacional de Cardiología Ignacio Chávez/MX
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