Rol del riñón en la hipertensión sal-sensible / Role of the kidney in salt sensitive hypertension
Rev. méd. Chile
;
138(7): 862-867, July 2010. ilus
Article
in Spanish
| LILACS
| ID: lil-567592
ABSTRACT
An important proportion of patients with essential hypertension are salt sensitive, defined as those who experience signifcant blood pressure changes according to the amount of salt intake. They have a disturbance in the pressure induced natriuresis mechanism and their kidneys have functional and morphological alterations con-sistent with an acquired tubulointerstitial alteration, afferent arteriole damage and alteration of peritubular capillaries. All these alterations lead to disturbances in sodium load excretion under normal pressures. There is also an associated activation of kidney vasoconstrictor/salt retaining systems and a reduction in the vasodilator/ salt eliminating mechanisms. These alterations, that originate early in life, generate a new blood pressure level, that corrects natriuresis at the expense of a sustained hypertension.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Sodium Chloride, Dietary
/
Hypertension
/
Kidney
Type of study:
Diagnostic study
Limits:
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2010
Type:
Article
/
Project document
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