Síndrome X vs síndrome metabólico: entendiendo sus coincidencias y sus diferencias hacia una [quot ]nueva cardiología[quot ] / Syndrome X vs metabolic syndrome
Arch. cardiol. Méx
;
76(supl.4): S173-S188, oct.-dic. 2006.
Article
in Spanish
| LILACS
| ID: lil-568122
ABSTRACT
Himsworth in 1939 postulated that Diabetes Mellitus type 2 (DM2) was not only an insulin deficiency state but also a cellular insulin insensitivity disease. Thirty years later, DeFronzo and Reaven demonstrated that insulin resistance (IR) preceded and predisposed for DM2 and atherosclerotic-cardiovascular-disease (ACVD). Reaven was the first to point out the relationship between IR and with hyperglycemia, dyslipidosis, and hypertension as mediators for ACVD, creating the concept of Syndrome X (SX) in 1988. WHO and, thereafter, other medical societies and medical groups, mainly ATP-III, in 2002, based on the difficulty of diagnosing IR in a simple, reliable, and inexpensive way, proposed and published the Metabolic Syndrome (MS) concept, as a group of five variables, i.e., obesity, hyperglycemia, hypertriglyceridemia, low HDL, and hypertension, as an easy clinical approximation to suspect and treat an increased cardiometabolic risk. Nowadays, there are deep and extensive controversies on this issue; however, these controversies do not really exist since all discordant points of view are rather quantitative and not qualitative in nature. This article is aimed at differentiating and harmonizing the complementary concepts of SX and MS, at analyzing why MS is a good [quot ]clinical window[quot ] to look for IR and its underlying manifestations, and finally to accept that the MS concept complements, but does not substitute or antagonize, traditional scales used to asses cardiovascular risk, such as the Framingham scale.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Insulin Resistance
/
Metabolic Syndrome
Type of study:
Etiology study
/
Qualitative research
/
Risk factors
/
Systematic reviews
Limits:
Humans
Language:
Spanish
Journal:
Arch. cardiol. Méx
Journal subject:
Cardiology
Year:
2006
Type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Hospital Central Médico-Quirúrgica de Aguascalientes/MX
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