Inhibición de la transición de la permeabilidad mitocondrial y del daño por reperfusión miocárdica por ciclosporina A / Inhibition of permeability transition and myocardic reperfusion damage by cyclosporine A
Arch. cardiol. Méx
;
77(supl.4): S4-77-S4-81, oct.-dic. 2007. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-568716
ABSTRACT
INTRODUCTION: The results presented in this study indicate that the immunosuppressor cyclosporine A acts as a cardioprotective drug. METHODS: This effect was analyzed during development of reperfusion-induced arrhythmias after 5 min period of coronary ligation in hearts of rats under anesthesia. RESULTS: The results indicate that cyclosporine inhibits Ca(2+)-induced mitochondrial damage; furthermore, when given before coronary occlusion, at a dose of 20 mg/kg, effectively protects against the high incidence of arrhythmias and the fall in blood pressure induced by reperfusion. In addition, it inhibits the delivery of lactic dehydrogenase and creatine kinase enzymes to the plasma. CONCLUSIONS: We propose that the protective effect could be related with its well documented action to restrain Ca(2+)-induced damage of mitochondrial functions.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Myocardial Reperfusion Injury
/
Cyclosporine
/
Immunosuppressive Agents
Limits:
Animals
Language:
Spanish
Journal:
Arch. cardiol. Méx
Journal subject:
Cardiology
Year:
2007
Type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Instituto Nacional de Cardiología Ignacio Chávez/MX
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