Hipertensión arterial pulmonar / Pulmonary arterial hypertension
Arch. cardiol. Méx
;
76(supl.2): S69-S75, abr.-jun. 2006.
Article
in Spanish
| LILACS
| ID: lil-568843
ABSTRACT
Pulmonary arterial hypertension is a progressive and lethal disease for which there is no effective cure. In recent years, however, there has been a significant progress in the knowledge about the pathobiologic mechanisms involved in the characteristic vascular damage of this disease. Knowledge has evolved from the importance of the vasoconstriction component originally contemplated to the current concept of a preponderant abnormal (fibromuscular) proliferation. This conceptual evolution has resulted in new and attractive pharmacologic interventions in an attempt to interrupt this abnormal process of vascular remodeling. In this review, the interventions derived from this pathobiologic knowledge are analyzed and based on the most recent controlled clinical trials; an evidence-based therapeutic strategy is established.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Hypertension, Pulmonary
Limits:
Humans
Language:
Spanish
Journal:
Arch. cardiol. Méx
Journal subject:
Cardiology
Year:
2006
Type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Instituto Nacional de Cardiología Ignacio Chávez/MX
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