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Translocación bacteriana e infecciones en un modelo experimental de cirrosis en la rata / Bacterial translocation and infections in an experimental model
Runyon, Bruce A.
  • Runyon, Bruce A; University of Loma Linda. Hepatology Section. California. US
Gastroenterol. latinoam ; 21(2): 234-236, abr.-jun. 2010. tab
Article in English | LILACS | ID: lil-570014
ABSTRACT
In summary the carbon tetrachloride/phenobarbital of cirrhosis in rats mimics human cirrhosis very closely, with development of ascites and SBP. This model shows us that bacterial overgrowth occurs as cirrhosis progresses and that bacterial translocation from the gut to extra-intestinal sites is part of the early pathogenesis of SBP. SID with norfloxacin dramatically reduced translocation and SBP at the expense of grampositive overgrowth and infection with gram-positives and colonization with strange gram negatives. SID with TMP-SMZ actually delayed development of ascites and prolonged survival.
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Index: LILACS (Americas) Main subject: Peritonitis / Ascites / Bacterial Translocation / Liver Cirrhosis, Experimental Limits: Animals Language: English Journal: Gastroenterol. latinoam Journal subject: Gastroenterology Year: 2010 Type: Article Affiliation country: United States Institution/Affiliation country: University of Loma Linda/US

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Index: LILACS (Americas) Main subject: Peritonitis / Ascites / Bacterial Translocation / Liver Cirrhosis, Experimental Limits: Animals Language: English Journal: Gastroenterol. latinoam Journal subject: Gastroenterology Year: 2010 Type: Article Affiliation country: United States Institution/Affiliation country: University of Loma Linda/US