Hepatotoxicidad por verapamil: reporte de un caso / Liver injury due to treatment with verapamil: case report
Gastroenterol. latinoam
;
21(1): 27-29, ene.-mar. 2010. graf
Article
in Spanish
| LILACS
| ID: lil-570403
ABSTRACT
Drug induced liver injury is an infrequent adverse effect of Verapamil. It has been reported in about ten cases since 1981. We report a case of a middle-aged woman who received Verapamil in a dose of 120mg/d for eight weeks, developing a mixed hepatocellular and cholestatic pattern of liver injury without any symptoms. There was no evidence of eosinophilia. Liver function tests returned quickly to normal levels after discontinuation. As in previously reported cases, we hypothesize that this is an idiosyncratic mechanism of liver injury.
RESUMEN
La hepatotoxicidad es un efecto adverso infrecuente de verapamil, existiendo alrededor de 10 casos reportados desde 1981. Relatamos el caso de una mujer de edad media que presenta una alteración de las pruebas hepáticas con patrón mixto asociado al uso de verapamil 120 mg/d por 8 semanas sin síntomas asociados, la cual responde rápidamente a la suspensión de este fármaco. Al igual que en casos reportados previamente, planteamos como mecanismo de injuria una hepatotoxicidad idiosincrática por este medicamento.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Calcium Channel Blockers
/
Verapamil
/
Chemical and Drug Induced Liver Injury
Limits:
Female
/
Humans
Language:
Spanish
Journal:
Gastroenterol. latinoam
Journal subject:
Gastroenterology
Year:
2010
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Pontificia Universidad Católica de Chile/CL
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