The use of ozonized oil in the treatment of dermatophitosis caused by Microsporum canis in rabbits
Braz. j. microbiol
;
42(1): 274-281, Jan.-Mar. 2011. ilus, tab
Article
in English
| LILACS
| ID: lil-571400
ABSTRACT
The ozone is effective against most microorganisms due to its high oxidant power. Low concentrations and short-term contact are sufficient to inactivate bacteria, mold, yeast, parasites, seaweeds, protozoa and fungi. Microsporum canis is an important agent of dermatophitosis in human and animal. The aim of the current study was to assess the efficacy of ozonized oil over Microsporum canis in rabbits. Eighteen male New Zealand white rabbits, weight ranging from 2 to 3.2 kg were depilated in the cranial dorso-lateral and right caudal, and cranial and left caudal regions. The regions were inoculated with Microsporum canis, excepting the right caudal region, and were denominated TM, O, OM and M, respectively. After seven days, the treatment of lesions in TM began with 0.12g of terbinaphine 1 percent cream; in OM and O with 0.12g of ozonized oil; all animals were treated once a day for 28 days. Region M was not treated. Material was collected from those regions for cultivation in Sabouraud agar at day 28 of treatment. In the evolution of the treatment with terbinaphine, of 14 contaminated regions with Microsporum canis ten evolved to cure. With the ozonized oil, of 15 contaminations, four were cured. Clinically, that is, the macroscopic evaluation of lesions showed improvement in the TM and OM treated regions. We can conclude that there was statistical evidence of the protection action of the oil against the dermatophyte.
Full text:
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Index:
LILACS (Americas)
Main subject:
Tinea Capitis
/
Oils
/
Oxidants
/
Dermatomycoses
/
Arthrodermataceae
/
Microsporum
/
Antioxidants
Type of study:
Diagnostic study
/
Evaluation studies
Limits:
Animals
Language:
English
Journal:
Braz. j. microbiol
Journal subject:
Microbiology
Year:
2011
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Irmandade da Santa Casa de Misericórdia de São Paulo/BR
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